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Instructor Class Description

Time Schedule:

Leslie B. Zeman
BIOL 403
Seattle Campus

Physiological Mechanisms of Histology

Develops recognition of cellular structures with correlations to normal physiology and disease states. Lab projects cover harvesting, sectioning, and mounting tissue. Includes weekly scientific papers. Prerequisite: either a grade of 3.0 in either BIOL 220, B BIO 220, or TESC 140, or a minimum grade of 2.0 in BIOL 350 or BIOL 355; may not be taken for credit if credit earned in BIOL 360.

Class description

Lectures will introduce students to recognition of cells and tissues based on their appearance in light microscopy. Some TEM images will be used for clarification. The features of cells and tissues in light microscopy will be correlated to physiologic function at the molecular, organelle, cellular, tissue and organ level. Most tissues reviewed will be vertebrate animals, but some invertebrate tissues will be used comparatively. Genetic, functional and clinical correlations will be discussed. Please select either BIOL 360 or BIOL 403, as there is considerable overlap between these two classes.

During lab, students will practice identification of tissues based upon their appearance in light microscopy through guided exercises. In addition, students will be required to develop a lab project which includes a literature search on a topic of their choice (subject to approval), harvesting tissue or cytology specimens from a limited choice of vertebrate and invertebrate organisms, sectioning, staining and mounting the tissue and presentation of their project to the class with projection of relevant images from their histologic sections.

Student learning goals

Recognize different organelles, cells and tissues in metazoans. Describe how the microscopic anatomy informs the function of each cell and tissue.

Work independently to harvest, fix, embed, section, stain and mount tissue. Produce diagnostic-quality digital photomicrographs. Prepare a Power Point presentation at the level of a professional meeting.

Using examples from tissues in which a pathologic process has altered the structure or function, monitor and assess mastery of fundamental principles. Independently develop notes of identifying features of organelles, cells and tissues.

General method of instruction

There will be three 50-minutes lectures per week, plus each student will attend two 2-hour labs per week.

Recommended preparation

Introductory Biology 180-200-220 series with a minimum 3.0 average in Biology 220 or a minimum 2.0 average in either Biology 350 or Biology 355.

Class assignments and grading

Powerpoints for lecture will be posted in advance. Textbook and scientific readings posted weekly. Most students will need to come into lab for aditional time outside of scheduled lab times.

Lab practical (includes lecture material) #1 15% Lab practical (includes lecture material) #2 17.5% Lab practical (includes lecture material) #3 17.5% Class project (includes peer evaluaion) 50%


The information above is intended to be helpful in choosing courses. Because the instructor may further develop his/her plans for this course, its characteristics are subject to change without notice. In most cases, the official course syllabus will be distributed on the first day of class.
Additional Information
Last Update by Leslie B. Zeman
Date: 12/04/2013