Edward J Kelly
Offered at a graduate level periodically by faculty members within the Department of Bioengineering; concerns areas of research activities with current and topical interest to bioengineers. Prerequisite: undergraduate or graduate courses (or equivalent) determined individually for each special topic.
Basic principles of pharmacokinetics and their application to the clinical setting, including: single-dose intravenous and oral kinetics, multiple dosing, nonlinear pharmacokinetics, metabolite kinetics, pharmacogenetics, and the role of disease in drug clearance and dose requirements, and kinetics of drug-drug interactions.
Student learning goals
• Understand basic principles of pharmacokinetics; linear and non-linear • Understand Pharmacokinetic-Pharmacodynamic relationships • Define drug-drug interactions and the role of metabolites in safety testing • Explain the role of variables (genetic, age, disease) on pharmacokinetics • Operation of pharmacokinetic software packages
General method of instruction
Didactic with alternating class room and online instruction. There will also be a series of laboratory classes using PK software packages.
Class assignments and grading
There will be two take home midterm exams and a final course presentation.