Review of basic mechanisms of transport; transport through vascular system and blood-tissue exchange processes in organs; integrated system analysis of closed systems and applications to physiological regulation, medical imaging, and pharmacokinetics. Prerequisite: calculus, introduction to differential equations; cardiovascular physiology; E E network analysis or systems analysis, chemical engineering transport.
This is a course on transport, exchange, and reaction in cells, organs and tissues. Only about 10% is covered in chemical engineering transprot courses. What is different is the emphasis on cells, cell membrane transporters, ionic pumps, exchangers, and electrophysiology, interstitial transport, high affinity binding and volumes of distribution, irreversible thermodynamic approach to coupled water and solute fluxes, enzymatic reactions in thermodynamically constrained systems of reactions, cooperativity, kinetics of imaging agents for metabolic assessment, fractal kinetics in transorgan impulse responses, blood rheology, tracer kinetics, biological bases for pharmacokinetics/pharmacodynamics and drug release/delivery.
Student learning goals
General method of instruction
Blackboard lectures with problems
Courses in cardiovascular and respiratory and renal physiology; physical chemistry and biochemistry; Chemical engineering transport; elementary fluid mechanics; reaction kinetics
Class assignments and grading
Systems analysis applied to biological transport; modeling analysis of data; generation of models for transport processes; uses of simulation tools; interpretation of models and data in terms of biological function; problem solving with quantitation
Mid term and final 50%. Homework problems 25% Presentation of analysis project 25%