Herbert M Sauro
Covers advanced concepts in system and synthetic biology. Includes kinetics, modeling, stoichiometry, control theory, metabolic systems, signaling, and motifs. All topics are set against problems in synthetic biology. Prerequisite: either BIOEN 401, BIOEN 423, E E 423, or CSE 486. Offered: jointly with E E 424/CSE 487; W.
This course offers an advanced course on system and synthetic biology. The course is designed for seniors and/or graduates who have an interest in bioengineering at the cellular network level. Topics include kinetics, modeling, stoichiometry, control theory, metabolic systems, signaling, motifs and a one week project. All topics are set against problems in synthetic biology. Every week one day is devoted to a journal club where students are expected to discuss the latest research and application papers in synthetic biology.
Student learning goals
To understanding the basic principles of building models of cellular networks.
Be able to choose and apply appropriate analytical and numerical tools to solve a given problem.
Be able to go from a functional requirement to a concrete design.
To apply principles of control theory to problems in synthetic biology.
To understand the operating principles of genetic, signal and metabolic systems.
General method of instruction
Lectures, discussion sessions and a weekly journal club.
Basic molecular biology
Class assignments and grading
Mainly computational which require software writing (Matlab, Octave, Python or some other suitable tool).
30% Homework Assignments 20% Midterms and Journal Club Participation 50% Final Team Project