The purpose of this FOA is to solicit applications for the Accelerating Medicines Partnership (AMP) in Rheumatoid Arthritis (RA) and Lupus Network Leadership Center. The AMP RA and Lupus Network is designed to ascertain and define shared and disease-specific biological pathways in order to identify relevant drug targets for the treatment of autoimmune diseases. This program will involve an enhanced systems-level understanding of gene expression and signaling in target tissues from affected end organs and peripheral blood cells.
The Network Leadership Center will: (i) direct and coordinate the scientific activities of the Network; (ii) monitor and evaluate scientific progress and performance; (iii) define Network research priorities; (iv) develop the Network research agenda; (v) provide centralized scientific/technical research resources for data management/coordination, statistical design/analyses and tissue acquisition; and (vi) conduct systems biology and bioinformatics research.
A companion FOA will establish the Network Research Sites, including: (i) Clinical Research Sites to assemble patient cohorts and obtain comprehensive clinical and laboratory data and relevant specimens to enable deconstruction of key events in cells and tissues related to disease, disease severity, and response to therapy; (ii) Technology Research Sites to develop, test, standardize and validate advanced and new technologies to identify critical signaling pathways in cells and tissues; or (iii) Combined Clinical and Technology Research Sites to conduct clinical and early validation studies of novel technologies and analytics in rheumatoid arthritis, lupus and related autoimmune diseases.
Awardees under both FOAs will work collaboratively to establish the AMP RA and Lupus Network.
Please submit a two-page letter of intent with a list of all anticipated investigators, description of proposed aims and approach, Biosketch of the PI, and a letter of support from the Dean or Chair to firstname.lastname@example.org by 5:00 PM Thursday, April 17, 2014. Full proposals are due to the sponsor on 5/21/14, so you will need to have your materials in to the Office of Sponsored Programs by 5/14/14 for processing, if given the go ahead by the Proposal Review Committee.
Investigators who identify a grant, award or fellowship program that restricts the number of applications that can be submitted from an Institution should immediately contact their Chairperson, Associate Dean for Research (or Dean, if no ADR) and the Office of Research (see below) if they intend to prepare a response. Failure to do so, or to meet the deadlines for submission of pre-proposal, will preclude submission of the application through the Office of Sponsored Programs.
For general inquiries, or to request a listing of a limited submission opportunity that should be but is not already listed, please email us at email@example.com.