The purpose of this Funding Opportunity Announcement (FOA) is to continue to increase the amount of publicly available, high-quality data describing structures and affinities of protein-drug ligand complexes -data vital for development, validation, and benchmarking of drug docking and screening software. Accurate and robust methods for in silico drug screening are expected to speed drug discovery and reduce drug development cost by focusing experimental efforts on the most promising candidate compounds. The ability to predict side effects resulting from off-target binding and to increase repurposing of existing pharmaceuticals is an additional expected benefit.
This FOA solicits applications to maintain, expand and enhance the existing NIGMS-funded Drug Docking and Scoring Data Resource by (i) maintaining strong working relationships with current and past data donors from the pharmaceutical industry and academia; (ii) recruiting new donors of unique datasets valuable to the docking and screening software effort; (iii) optimizing the value of these datasets by adding a limited amount of carefully chosen new experimental results; (iv) maintaining the existing Data Resource contents and integrating them with new data and with information from other sources, such as the Protein Databank; and (v) making all Resource data freely and efficiently available for use by the in silico drug docking and screening community.
Please submit a two-page letter of intent with a list of all anticipated investigators, description of proposed aims and approach, Biosketch of the PI, and a letter of support from the Dean or Chair to firstname.lastname@example.org by 5:00 PM Thursday, August 8, 2013. This letter of support signifies that the Dean or Chair have ensured that the nominee and application are likely to be of sufficient quality to be competitive nationally. Full proposals are due to the sponsor on 10/10/13, so you will need to have your proposal to the Office of Sponsored Programs by 10/3/13 for processing, if given the go ahead by the Proposal Review Committee.
Investigators who identify a grant, award or fellowship program that restricts the number of applications that can be submitted from an Institution should immediately contact their Chairperson, Associate Dean for Research (or Dean, if no ADR) and the Office of Research (see below) if they intend to prepare a response. Failure to do so, or to meet the deadlines for submission of pre-proposal, will preclude submission of the application through the Office of Sponsored Programs.
For general inquiries, or to request a listing of a limited submission opportunity that should be but is not already listed, please email us at email@example.com.