UW Today

Health sciences digest: Drug pricing uproar, antioxidant dangers

The latest news from the UW Health Sciences and UW Medicine:   What price for a cure? The economics of drug pricing The uproar against the $1,000-a-pill hepatitis C drug Sovaldi, generic name sofosbuvir, may signal a turning point in drug pricing in the United States.  Purchasers appear to be pushing back and saying, “No.”

Match Day, when medical student futures are decided

The official announcement of the results of the National Residency Matching Program is an annual rite of passage for UW medical students and their peers across the United States. The wait is over.

Newly found tactics in offense-defense struggle with hepatitis C virus

People who are genetically equipped to stop hepatitis C viruses from turning off a type of interferon generally have a robust antiviral response. Findings on the mechanisms governing this ability suggest new avenues for treatment research.

Neanderthal lineages excavated from modern human genomes

A fossil-free method of sequencing archaic DNA may provide insight into human evolution.

Cognitive training shows some lasting effects in healthy older adults

The national, decade-long ACTIVE study showed that cognitive training can help the elderly maintain certain thinking and reasoning skills useful in everyday life.

Psychiatry’s Jeremy J. Clark receives Presidential Early Career Award

Clark was recognized for his work in the neurobiology of motivated behavior. His award will support investigations of how alcohol exposure during the teen years might lead to chronic alcoholism in adults.

TB bacteria mask their identity to intrude into deeper regions of lungs

Cell surface lipids hide molecular patterns that infection-killing cells might recognize as dangerous.

How living cells solved a needle in a haystack problem to generate electrical signals

Filtered from a vast sodium sea, more than 1 million calcium ions per second gush through our cells’ pores to generate charges

FDA-approved immune-modulating drug unexpectedly benefits mice with fatal mitochondrial defect

Rapamycin, an anti-rejection drug for organ transplant patients, has now been shown to increases survival in and delayed symptoms of Leigh’s syndrome. The drug appears to cause a metabolic switch that bypasses the mitochondrial deficiency.

Cost-effective method accurately orders DNA sequencing along entire chromosomes

The method may help overcome a major obstacle that has delayed progress in designing rapid, low-cost — but still accurate — ways to assemble genomes from scratch. It also may validate certain types of chromosomal abnormalities in cancer.

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