UW News

March 29, 2013

Head-on collisions between DNA-code reading machineries accelerate gene evolution

Houra Merrikh Samuel Million-Weaver

Bacteria speed up their evolution by positioning specific genes along the route of expected traffic jams in DNA encoding. Collisions can result in mutations.

March 8, 2013

Spring move-in slated for new UW Medicine South Lake Union research building

Window wipers scale the new UW Medicine South Lake Union research building.

Occupying the seven-story facility will be labs for kidney research, vision sciences, immunology, rheumatology, and infectious disease investigations.

February 15, 2013

Flu researcher whose findings met U.S. biosecurity review to speak at UW

University of Wisconsin- Medicine School of Veterinary Medicine professor Dr. Yoshihoro Kawaoka will speak Jan. 19 at the UW on pandemic influenza.

The review generated public debate on publishing legitimate biological science findings that could pose a threat to public health or national security,

January 10, 2013

Multiple sclerosis study reveals how killer T cells learn to recognize nerve fiber insulators

A micrograph of a killer T cell, a white blood cell with the job of destroying germs or cancers, but that can sometimes attack the body's own normal cells.

Misguided killer T cells may be the missing link in sustained tissue damage in the brains and spines of people with multiple sclerosis, research in immunologist Joan Goverman’s lab suggests.

December 27, 2012

Academic medicine has major economic impact on the state and the nation

The Washington state business volume impact of publicly funded research conducted at Association of American Medical Colleges-member institutions was nearly $1.8 billion in 2009.

The Association of American Medical Colleges reports that its member medical schools and teaching hospitals had a combined economic impact of more than $587 billion in the United States in 2011

December 20, 2012

Mild brain cooling after head injury prevents epileptic seizures in lab study

EEG superimposed over images of a brain.

Traumatic head injury is the leading cause of acquired epilepsy in young adults, and at present there is no treatment to prevent or cure it.

December 13, 2012

Dark Ages scourge enlightens modern struggle between man and microbes

Yersinia (gray) infects two macrophages. In the upper right pyroptosis was subverted via YopM, in the bottom left, pyroptosis is induced and an inflammasome is formed (white).

Discoveries reported today help explain how the stealthy agent of Black Death avoids tripping a self-destruct mechanism inside germ-destroying cells.

November 29, 2012

Rules devised for building ideal protein molecules from scratch

Rie (right) and Nogu Roga are a wife-and-husband scientific team who research protein design.

These principles could allow scientists to custom-make, rather than re-purpose, protein molecules for vaccines, drugs, and industrial and environmental uses.

November 28, 2012

Harmful protein-coding mutations in people arose largely in the past 5,000 to 10,000 years

Joshua Akey.

The spectrum of human genetic diversity today is vastly different than what it was only 200 to 400 generations ago.

November 19, 2012

Mutations in genes that modify DNA packaging result in form of muscular dystrophy

Dr. Daniel Miller studies the molecular basis of muscle disorders in his lab at UW Medicine South Lake Union.

Studying the molecular basis of progressive muscle weakness may lead to therapies to prevent or reduce symptoms.

November 8, 2012

Extra chromosome 21 removed from Down syndrome cell line

An image of the Down syndrome trisomy, showing an extra chromosome 21.

The approach could lead to cell therapy treatments for some of the blood-forming disorders that accompany the common genetic condition.

October 18, 2012

2012 Nobel Laureate in Chemistry Brian Kobilka will speak at UW Oct. 23

Brian Kobilka at his molecular and cellular physiology lab at Stanford University. Kobilka trained as an internal medicine physician before going into basic science research.

The Stanford University faculty member will talk about a group of cell membrane receptors that are crucial for emotion, behavior, memory, vision, motion and many other activities. About 40 percent of medications act via these receptors.

September 27, 2012

Dynamics of DNA packaging helps regulate heart formation

A view inside the heart regeneration laboratory of UW Medicine cardiac pathologist Dr. Charles Murry.

Findings suggest new ways to study controls of early human development, causes of birth defects, and regeneration of damaged tissue.

September 18, 2012

Local scientists chosen for NIH High Risk High Rewards program


The scientists were selected for their inventive ideas to transform their field of research and improve the health of the public.

September 13, 2012

After months on portable artificial heart, Alaska man receives transplant

The artificial heart has been removed and surgeons prepare to place the donor heart into Christopher Marshall's chest.

Christopher Marshall underwent a seven-hour heart transplant surgery yesterday, Sept. 12, a UW Medical Center.

September 6, 2012

Hospitals that make longer attempts at resuscitation have higher survival rates

Medical staff at a naval hospital practice CPR on mannequin during a Code Blue drill. No clear guidelines exist for hospitals on how long to continue resuscitation before ending the attempt.

Findings challenge the assumption that, if a pulse is not restored soon, continuing resuscitation efforts is futile.

September 5, 2012

Encyclopedia of DNA elements compiled; UW a key force in Project ENCODE

UW genome scientist Dr. John A. Stamatoyannopolous led several major Project ENCODE related studies.

An international team of researchers has made headway toward a comprehensive listing of all the working parts of the human genome. More than 30 scientific papers appear today, include major work by UW researchers. The London Museum of Science celebrates with ceiling banners and aerial dancers.

Millions of DNA switches that power human genome’s operating system are discovered

This illustration depicts DNA packed tightly into chromosomes, as well as a DNA molecule unwound to reveal its 3-D structure.

Scientists created comprehensive maps of elusive gene-controlling DNA and a dictionary of the human genome’s programming language

Researchers unlock disease information hidden in genome’s control circuitry

DNA molecule unwinding from a chromosome inside the nucleus of a cell

Most genetic changes linked to more than 400 common diseases affect regions of DNA that dictate when genes are switched on or off. Many of these changes affect circuits active during early human development.

August 27, 2012

Alaska cruise passenger airlifted to Harborview for blood clot treatment

Sarah Davis at Harborview with husband after airlift from Alaska cruise

Sarah Davis took an unexpected side trip during an Alaskan cruise last week. While the Beaufort, S.C., resident was admiring the rugged scenery with her family, she developed debilitating pain in her leg. In the middle of the night,the ship’s physician diagnosed a dangerous blood clot. At 2:30 a.m. Aug. 21 in Seattle, UW Medicine…

August 22, 2012

Low-dose sedative alleviates autistic-like behavior in mice with Dravet syndrome mutation

artists concept of brain cell-to-cell signaling

UW researchers have found that a low dose of the sedative clonazepam alleviated autistic-like behavior in mice with a mutation that causes Dravet syndrome in humans.

August 20, 2012

Molecular and protein markers predict liver transplant failure in hepatitis C patients

Surgeons performing a liver transplant at UW Medical Center

Researchers have discovered molecular and protein signatures that predict rapid onset of liver damage in hepatitis C patients following a liver transplant. The markers appeared soon after transplant and well before clinical evidence of liver damage. Such early detection of susceptibility to hepatitis C virus-induced liver injury could lead to more personalized monitoring and treatment…

August 5, 2012

Muscle cell grafts keep broken hearts from breaking rhythm

laflamme frozen cells

Researchers have made a major advance in efforts to regenerate damaged hearts. They discovered that transplanted heart muscle cells, grown from stem cells, electrically couple and beat in sync with the heart’s own mucle. The grafts also reduced the incidence of arrhythmias (irregular heart rhythms) in a guinea pig model of myocardial infarction (commonly known…

July 27, 2012

Seattle researchers to engineer kidney tissue chip for predicting drug safety

An example of an organ on a chip, in this case, a lung.

Seattle researchers will be part of the new federal initiative to engineer 3-dimensional chips containing living cells and tissues that imitate the structure and function of human organs.┬á These tissue chips will be used for drug safety testing. Tissue chips merge techniques from the computer industry with those from bioengineering by combining miniature models of…

July 16, 2012

UW study plays pivotal role in todays FDA approval of HIV prevention drug

In evaluating whether to allow Truvada® to be prescribed for HIV prevention the FDA reviewed evidence from two studies. The largest was conducted by the UWs International Clinical Research Center.

July 13, 2012

UW Medicine opens comprehensive Multiple Sclerosis Center at Northwest Hospital

The public is invited to an open house from 11 a.m. to 2 p.m., Saturday July 21 at the facility, which has one of the regions strongest concentrations of MSspecialists.

July 11, 2012

Groundbreaking research paves way for HIV prevention drug approval

The UW International Clinical Research Center played a key role in examining Truvada’s effectiveness for HIV prevention. The center’s director Connie Celum talks about the impact of the findings in a Q & A.

July 9, 2012

NIH award advances Institute of Translational Health Sciences groundbreaking work

ITHS helps scientists accelerate the translation of their discoveries into applications for improving the health of the public. The latest award is for $65 million.

July 8, 2012

Exome sequencing of health condition extremes can reveal susceptibility genes

DNA from cystic fibrosis patients with and without chronic infections points to unsuspected mutation.

June 20, 2012

From the mouths of monkeys: New technique detects TB

Tuberculosis can be a serious threat to monkeys and apes. A test to spot infection might help protect the world’s primate populations.

June 6, 2012

Babys genome deciphered prenatally from parents lab tests

A maternal blood sample and a paternal saliva specimen contained enough information to map the fetus DNA.

June 1, 2012

Computer-designed proteins programmed to disarm a variety of flu viruses

Construction plans for tiny molecules to stop flu viruses from infecting cells may help in fighting other pathogens.

May 22, 2012

Long-distance training teaches proper technique for asthma test

The virtual teaching of health professionals translates to better asthma care for patients.

May 18, 2012

Blues singer Mark Lanegan releases 'Harborview Hospital'

In the song on his latest album, a pause at Ninth and James turns into a mystical vision of mercy.

May 17, 2012

Slew of rare DNA changes following population explosion holds clues to common diseases

Scientists try to find which single-letter switches in the genetic code influence health risks.

May 15, 2012

Insulin nasal spray therapy shows memory improvement in Alzheimers patients

A year-long, multi-site clinical trial of insulin nasal spray has been called a significant step forward in measuring the safety and effectiveness of a promising treatment.

May 8, 2012

UW to collaborate on biodefense drug development

The $8.1 million grant will fund work on new drugs against some of the world’s most deadly infectious diseases.

May 3, 2012

Human brain evolution tied to partial gene copy that blocks original

A brain-development gene incompletely duplicated about time of the transition of pre-human to more human-like beings.

May 1, 2012

Researchers determine Vitamin D blood level for reducing major medical risks in older adults

How much Vitamin D do older adults need to stay healthy? The level may be lower than many think.

April 27, 2012

‘Attack! of the S. mutans’ 3-D video game featured at national science expo

'Attack! of the S. mutans' 3-D video game featured at national science expo

When tooth-decaying bacteria are on the loose, destroy those oozing biofilms in a interactive School of Dentistry game.

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