This is an archived article.

January 6, 2000

HIV virus can alter the way genes function within days of exposure

According to a University of Washington study published in the January 2000 issue of Virology, genes involved in T-cell signaling, protein trafficking and transcriptional regulation were among the genes that displayed functional changes within three days of exposure to the HIV virus.

The study examined the level or “expression” of approximately 1,500 genes in cells that were deliberately infected with the HIV virus. “By using gene expression microarrays, we discovered cellular changes in the expression levels of at least 20 different genes by day three of our study,” said Dr. Gary K. Geiss, a senior fellow at the UW?s Department of Microbiology who directed the laboratory research.

Amersham Pharmacia Biotech, which helped to develop a state-of-the-art microarray facility for the UW Department of Microbiology and the Washington Regional Primate Research Center.

For more information contact Dr. Roger Bumgarner at (206) 685-7307.