University of Washington School of Medicine
Seattle Children's
Department of Pediatrics Newsletter

DATE : 2009-09-25

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Items to be covered in this edition:

  1. Important Dates
  2. Welcome to New Faculty & Changes in Current Faculty
  3. Faculty News
  4. Faculty Publications and Presentations

top I. IMPORTANT DATES

September 28: Visiting Scientist Seminar. 11:45-12:45 in Soundgarden, Bldg 1. “Progress towards treatment of SCID-X1 with self-inactivating lentiviral vectors” presented by Brian Sorrentino, MD, Director, Experimental Hematology; Member, Department of Hematology; St. Jude Children's Research Hospital. Hosted by David Rawlings, MD and Andrew Scharenbeg, MD.

September 28: Royalty Research Fund (RRF) Proposal Deadline. The proposal submission and review process is electronic; all proposals will be submitted using SAGE (System to Administer Grants Electronically). Proposals for the fall round are due Monday, September 28, by 5:00 pm. The RRF application instructions are available at the Office of Research web site: http://www.washington.edu/research/main.php?page=rrf.

September 29: Visiting Scientist Seminar. 1:30-2:30 in Soundgarden, Bldg 1. “Utilization of Mouse Mutants and Strain Variation to Understand Human Development and Disease” presented by Dr. David Beier.

October 1: GME and Medical Student Office Open House, 12:00–1:00 pm, A-5950, just down the hall from the cafeteria (or just inside the Airplane entrance on the 5th Floor at Children’s). The GME Office, Medical Student and Residency Programs all moved this summer to a new location on the 5th floor of the Airplane wing. They are holding an Open House in the hopes that you will visit the new space and get familiar with the new surroundings. For those who will be assisting in conducting residency interviews during this year’s recruitment season, this is a great chance to come see where your interviewees will be waiting for you.

October 5: Meeting of Professors and Associate Professors to discuss mandatory promotions. 7:30-9:00 AM, Wright Auditorium. Contact Diane Wade (dmw@uw.edu or 206-987-1713) with questions. (Rescheduled from 9/22).

October 21: Promotion Criteria meeting. 5-6:30pm W-3747B. Acting Instructors, Acting Assistant Professors, Assistant Professors, Research Assistant Professors, New Faculty and Interested Faculty: Chris Gleason and Fred Rivara give a talk annually for faculty on promotion criteria for different faculty tracks and the promotion process. The goal is to take some of the mystery out of the process, help you think ahead to what are the components of the promotion packet that need to be assembled, and to prepare now to make this process less stressful. This is intended for junior faculty as well as all new faculty so that all can understand the criteria and process. Please RSVP to Diane Wade (dmw@uw.edu) if you would like to attend.

October 28: Department of Pediatrics Faculty Meeting. 5:30-8:00pm in Wright Auditorium. The topics will be: a presentation of Children’s University Medical Group (our practice plan); A presentation of our CPI staff on how to use a tool called the A3 to do spot improvements using the Toyota system in your areas. These two topics were specifically requested by our faculty and the program should be very informative and interactive. Contact Diane Wade (dmw@uw.edu or 206-987-1713) with questions.

November 5: The Lana Staheli Endowed Lecture followed by the Annual Work-Life Balance Symposium. The theme for the day will be “Survive and Thrive: Promoting Resilience and Balance among Pediatric Health Care Professionals”, and will feature guest lecturer, Dan Shapiro, PhD, who is Professor and Chair of the Humanities Department at Penn State College of Medicine. Contact Kathie Kohorn with questions: kathie.kohorn@seattlechildrens.org

top II. WELCOME TO NEW FACULTY & CHANGES IN CURRENT FACULTY

Name

Rank

Division

Margaret Adam, MD

Associate Professor

Genetics

Francois Aspesberro, MD

Assistant Professor

Critical Care Medicine

Christina Gerhardt, MD

Assistant Professor

Endocrinology

Jessica McMeekin, RN, MSN, PNP

Teaching Associate

Hematology/Oncology

Mohamed Oukka, PhD

Assistant Professor

Immunology

William Van Cleve, MD

Acting Instructor/Senior Fellow

General Pediatrics

Changes in Current Faculty Appointments

Anne Leavitt, MD

FTCF-Clinical Assistant Professor

Developmental Medicine

Sarah Ringold, MD

Acting Assistant Professor

Rheumatology

Elisabeth Villavicencio, MD, PhD

FTCF-Clinical Assistant Professor

Hospital Medicine

Maneesh Batra, MD, MPH

Adjunct Assistant Professor

Department of Global Health

top III. FACULTY NEWS

Jackie Starr, PhD, and Carrie Heike, MD, MS, Division of Craniofacial Medicine, have been awarded a 2-year, 1 million dollar RC1 Challenge Grant entitled: "Planning Grant for Genome-Wide Association Study of Craniofacial Microsomia". Dr. Starr and Heike will lead this multicenter planning grant involving investigators from Seattle Children’s Craniofacial Center, the University of Washington Departments of Pediatrics and Genome Sciences, Children's Hospital of Philadelphia, the University of North Carolina, Children’s Hospital of Los Angeles, the University of Illinois Medical Center, the Children’s Hospital of Pittsburgh, and Axio Partners in Research will lead to a whole genome association study for craniofacial microsomia.

Maureen Kelley, PhD: Greenwall foundation 25,000 Research Participation with Wards of the State: Evaluating IRB and Investigator Perspectives.

Lincoln Smith, MD: K08 application titled "Development Mechanisms in Acute Lung Injury" has been funded.

Aaron Olson, MD: 5 year K08, Metabolic Substrate Utilization During c-Myc Induced Cardiac Hypertrophy was awarded $128,979.

Ryan McAdams, MD: UW Institute of Translational Health Sciences (ITHS) Small Pilot Grant Award: “Determining mechanisms of fetal lung injury in utero following intrauterine infection in a non-human primate model”

Michael Bamshad, MD will serve as a member of the Genetics of Health and Disease Study Section, Center for Scientific Review, for the term beginning immediately and ending June 2015.

Ann Woolfrey, MD has been elected to the Board of Directors of the National Marrow Donor Program

top IV. FACULTY PUBLICATIONS AND PRESENTATIONS

Aaron Olson, MD presented in a moderated poster session at the 7th Annual Scientific Sessions of the Society for Heart and Vascular Metabolism Meeting in Padova, Italy in August. Dr. Portman was a co-author. The title of the abstract was “Triiodothyronine Promotes Pyruvate Entry into the Citric Acid Cycle after Reperfusion in Neonatal Pigs: an Energetic Basis for Improved Contractility”

Jackie Starr, PhD: Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer. Nat Genet. 2009 Jul;41(7). Kanetsky PA, Mitra N, Vardhanabhuti S, Li M, Vaughn DJ, Letrero R, Ciosek SL, Doody DR, Smith LM, Weaver J, Albano A, Chen C, Starr JR, Rader DJ, Godwin AK, Reilly MP, Hakonarson H, Schwartz SM, Nathanson KL.

Carrie Heike, MD, MS, and Jackie Starr, PhD: Single nucleotide polymorphism discovery in TBX1 in individuals with and without 22q11.2 deletion syndrome.. Birth Defects Res A Clin Mol Teratol. 2009 Jul 30. Heike CL, Starr JR, Rieder MJ, Cunningham ML, Edwards KL, Stanway IB, Crawford DC.

Michael Cunningham, MD, PhD, and Jackie Starr, PhD: A case-control study of infant, maternal and perinatal characteristics associated with deformational plagiocephaly. Paediatr Perinat Epidemiol. 2009 Jul;23(4):332-45. McKinney CM, Cunningham ML, Holt VL, Leroux B, Starr JR.

Yemi Kifle, MD, and Jackie Starr, PhD: Sleep outcomes in children with hemifacial microsomia and controls: a follow-up study. Pediatrics. 2009 Aug;124(2):e313-21. Cloonan YK, Kifle Y, Davis S, Speltz ML, Werler MM, Starr JR.

Mark Del Beccaro, MD, and Howard Jeffries, MD: “Pediatric emergency and pediatric critical care considerations.” Pediatric Informatics: Computer Applications in Health Care. Eds. Lehmann CU, Kim GR, Johnson KB. New York: Springer, 2009. 69-79. Del Beccaro MA, Jeffries HE, Kim GR.

Ryan McAdams, MD: Complications of umbilical artery catheterization in the immature baboon. J Perinatology 2009 Jun 25 [Epub ahead of print]. McAdams RM, Winter VT, McCurnin DC, Jacqueline J.

Jessica Slusarski, MD, Ron McPherson, PhD, and Sandra Juul, MD, PhD: High-dose erythropoietin does not exacerbate retinopathy of prematurity in rats. Pediatr Res 2009 Aug, Epub ahead of print. Slusarski JD, McPherson RJ, Wallace GN, Juul SE.

Ron McPherson, PhD and Sandra Juul, MD, PhD: Postnatal stress produces hyperglycemia in adult rats exposed to hypoxia-ischemia. Pediatr Res 2009;66:278-82. McPherson RJ, Mascher-Denen M, Juul SE.

Carl Koschmann, MD (pediatric resident), Blythe Thomson, MD, Douglas S. Hawkins, MD: No evidence of a trial effect in newly diagnosed pediatric acute lymphoblastic leukemia. C Koschmann, B Thomson, DS. Hawkins. Accepted by Archives of Pediatrics and Adolescent Medicine

W. Alan Hodson, MD: The Neonate. In: The Child: An Encyclopedic Companion, RA Schweder, TR Bidel, AC Dailey, et al (eds). The University of Chicago Press, Chicago IL, 2009 September.

Doug Opel, MD, Ben Wilfond, MD, and Doug Diekema MD, MPH: Characterisation of organisational issues in paediatric clinical ethics consultation: a qualitative study J. Med. Ethics 2009;35;477-482. DJ Opel, BS Wilfond, D Brownstein, DS Diekema and RA Pearlman.

Benjamin S. Wilfond, MD: Pediatric Biobanks: Approaching Informed Consent for Continuing Research After Children Grow Up. Aaron J. Goldenberg, Sara Chandros Hull, Jeffrey R. Botkin, and Benjamin S. Wilfond. J Pediatr 2009

Doug Diekema MD, MPH: Clinical Report: Forgoing Medically Provided Nutrition and Hydration in Children. Pediatrics 2009; 124: 813-822. Diekema DS, Botkin JR, and the Committee on Bioethics, American Academy of Pediatrics.

Sheela Sathyanarayana MD, MPH:

  1. Phthalates and other additives in plastics: human exposure and associated health outcomes. Philos Trans R Soc Lond B Biol Sci. 2009 Jul 27;364(1526):2097-113. Meeker JD, Sathyanarayana S, Swan SH.
  2. Problem with Plastics. AAP News. American Academy of Pediatrics 2009 Aug;30(8):29. Sathyanarayana S.

Joseph T. Flynn MD, MS:

  1. Should the approach to evaluation and treatment of high blood pressure in children be changed? (editorial). Journal of Pediatrics, 155:157-158, 2009. Flynn JT, Falkner BE.
  2. The importance of blood pressure screening in children (letter). Journal of Pediatrics, 155:299, 2009. Flynn JT, Falkner BE.

Cora Breuner, MD, MPH:

  1. Adolescence and the use of herbs. Int J Disabil Hum Dev 2009; 8(2): 125-127.
  2. Complementary and alternative medicine and eating disorders. Int J Disabil Hum Dev 2009; 8(2):129-133.

Timothy Cox, PhD:

  1. Lack of association between the A118G polymorphism of the mu opioid receptor gene (OPRM1) and opioid dependence: A meta-analysis. Pharmacogen Pers Med. 2009; 2:9-10. Coller JK, Beardsley J, Bignold J, Li Y, Merg F, Sullivan T, Cox TC, Somogyi AA.
  2. 3D imaging of biomedical samples. In: Infrared and Raman Spectroscopic Imaging (eds. R. Salzer & H.W. Siesler). Wiley-VCH. p203-224. McNaughton, D., Wood, B.R., Cox, T.C., Drenckhahn, J.D. & Bambery, K.R.

Christian L. Roth, MD:

  1. Changes of peripheral alpha-melanocyte-stimulating hormone in childhood obesity. Metabolism. 2009 Sep 17. [Epub ahead of print] PubMed PMID: 19766264. Roth CL, Enriori PJ, Gebhardt U, Hinney A, Müller HL, Hebebrand J, Reinehr T, Cowley MA.
  2. Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease. Atherosclerosis. 2009 Jul 8. Linsel-Nitschke P, Heeren J, Aherrahrou Z, Bruse P, Gieger C, Illig T, Prokisch H, Heim K, Doering A, Peters A, Meitinger T, Wichmann HE, Hinney A, Reinehr T, Roth C, Ortlepp JR, Soufi M, Sattler AM, Schaefer J, Stark K, Hengstenberg C, Schaefer A, Schreiber S, Kronenberg F, Samani NJ, Schunkert H,
    Erdmann J.
  3. A novel melanocortin-4 receptor gene mutation in a female patient with severe childhood obesity. Endocrine. 2009 Aug;36(1):52-9. Roth CL, Ludwig M, Woelfle J, Fan ZC, Brumm H, Biebermann H, Tao YX.

*Please let us know of your latest publications, awards, and honors by emailing Brooke Freed.