Children's Hospital and Regional Medical Center
Department of Pediatrics Newsletter
DATE : 2007-07-27
ITEMS TO BE COVERED IN THIS NEWSLETTER:
Important Dates
Promotions
Clinic Improvements
Faculty News
Faculty Publications and Presentations
DEADLINE - Tuesday, July 31: Application for American Pediatric Society Due. www.aps-spr.org
August 16-19, 2007: The North Pacific Pediatric Society (NPPS) will have its 175th Conference at the Harrison Hot Springs Resort & Spa, in Harrison Hot Springs, British Columbia Canada. The program can be accessed on the Society's web site at
www.northpacificpediatricsociety.org
August 28-29, 2007: Washington State Adolescent Health Conference “PARTNERSHIPS FOR HEALTHY YOUTH”. Conference & Registration Information is now available at: http://www.regonline.com/phy2007
Monday, September 24, by 5:00 PM: The Autumn 2007 round of the Royalty Research Fund (RRF) Proposals are due Monday, September 24, by 5:00 PM. The application, packet, and information about previous awards may be found on the Office of Research website at: http://www.washington.edu/research/rrf.html. Contact the RRF program staff, Barbara Thompson (bthompso@u.washington.edu), and Peter Wilsnack (doogieh@u.washington.edu), if you have questions about the program.
September 28-29, 2007: Centennial celebration- Medical Symposium and Alumni reunion, Children’s Hospital and Grand Hyatt Seattle. The Symposium is complimentary.
All participants must pre-register. Space is limited and Registration will close August 1, 2007.
Contact Kathie Kohorn, CME Coordinator kathie.kohorn@seattlechildrens.org for the form.
DEPARTMENT OF PEDIATRICS PROMOTIONS
Dr. Julia Bledsoe, Clinical Professor
Dr. Dimitri Christakis, Professor
Dr. Mary Patricia Fairchok, Clinical Professor
Dr. Ian Glass, Professor
Dr. Karen Murray, Professor
Dr. Robert Jay Newman, Clinical Professor
Dr. Catherine Pihoker, Professor
Dr. James Stout, Professor
Dr. Carol Wallace, Professor
Dr. Harris Baden, Associate Professor
Dr. Christine Caldwell, Clinical Associate Professor
Dr. Paul Carpenter, Associate Professor
Dr. Steven Chapman, Clinical Associate Professor
Dr. Julian Davies, Clinical Associate Professor
Dr. Beth Ellen Davis, Clinical Associate Professor
Dr. Michael Dudas, Clinical Associate Professor
Dr. Beth Ebel, Associate Professor
Dr. Martin Goldsmith, Clinical Associate Professor
Dr. Troy Johnston, Associate Professor
Dr. Charlotte Lewis, Associate Professor
Dr. Ronald Louie, Clinical Associate Professor
Dr. Heather McPhillips, Associate Professor
Dr. Carol Miao, Research Associate Professor
Dr. Laura Richardson, Associate Professor
Dr. Robert Roskin, Clinical Associate Professor
Dr. Catherine Shubkin, Clinical Associate Professor
Dr. Kendra Smith, Clinical Associate Professor
Dr. W. Michelle Terry, Clinical Associate Professor
Dr. Cor Van Niel, Clinical Associate Professor
Dr. Rebecca Wiester, Clinical Associate Professor
Dr. Matthew Allen, Clinical Assistant Professor
Dr. Julianne Bishop, Clinical Assistant Professor
Dr. Monica Burnside, Clinical Assistant Professor
Dr. Monique Burton, Clinical Assistant Professor
Dr. Bruce Chandler, Clinical Assistant Professor
Dr. Tracie O’Neill, Clinical Assistant Professor
Special recognition in June goes to:
Cardiology – over 51% of scheduled new patient visits were within 14 days - MET GOAL: Total # of new visit appointments = 192
Craniofacial – 63% of scheduled new patients were within 14 days (improved from 44% in May) - MET GOAL: Total # of new visit appointments = 248
Endocrinology – 43% of scheduled new patient visits were within 14 days - MET GOAL FOR 3rd Quarter @ 50%: Total # of June new visit appointments = 110
GI – over 47% of scheduled new patient visits were within 14 days (improved from 44% in May), total # of new visit appointments = 212
Special recognition for median new appointment wait times in June goes to:
Cardiology – for dropping their wait time to 14 days (compared to 20-30 days last quarter)
Craniofacial – for dropping their wait time to 13 days (compared to 20-25 days last quarter)
GI – for dropping their wait time to 15 days (compared to 18-21 days last quarter)
Hem-Onc, ID/Virology, Orthopedics, Psychiatry and Transplant for having YTD median wait times of 14 or less.
Rheumatology for their YTD improvements (23 days compared to 33 days last year)
Fred Rivara, MD, MPH, has been named the Children’s Hospital Guild Association Endowed Chair in Pediatric Health Outcomes Research. Fred has also been named by Governor Gregoire to the Board of Directors of the Washington State Academy of Science.
Dr. Jane Burns will assume responsibility for overseeing the outpatient and inpatient clinical services for the Infectious Disease Section. Her new title is Clinical Director of Infectious Disease Services. She will work collaboratively with Jan Englund, Director of ID transplant services. Jane will be the point of contact for any issues regarding policies, procedures, and management of general Infectious Disease Services. Her new responsibilities began as of July 1, 2007.
Sam Moskowitz, MD, and Paolo Vicini (UW Dept of Bioengineering) have been awarded $20,000 in seed funding from the Coulter Foundation Translational Research Partnership for a project entitled, "Development of a system to simulate antibiotic treatment of CF lung infection.
Bruder Stapleton, MD, professor and chair of pediatrics, and Ford/Morgan Endowed Chair in Pediatrics, has been appointed associate dean of the UW School of Medicine. In his capacity as associate dean, he will coordinate student and graduate medical education between Children's Hospital and the UW School of Medicine, and research programs for faculty based at Children's Hospital. In these activities, he will work with the vice deans responsible for research, graduate medical education, and academic affairs for UW Medicine. Stapleton will serve as a liaison between UW departments and Children's Hospital regarding educational and research initiatives within the Children's Hospital strategic plan, in close collaboration with Hendricks in his position as assistant dean.
James Hendricks, PhD, clinical professor of pediatrics and president of the Children's Hospital Research Institute, has been named assistant dean of research and graduate medical education in the School of Medicine. Hendricks will work closely with the vice dean for research and graduate education in coordinating research activities that involve UW faculty based at Children's Hospital, particularly in the areas of compliance, research infrastructure, and research facilities. Hendricks will work closely with Stapleton in facilitating coordination of faculty research activities between the UW and Children's Hospital.
Dr. Janet Englund was appointed to the Advisory Committee on Immunization Practices of the Centers for Disease Control and Prevention, beginning July 1, 2007.
Daryl Okamura, MD, has been awarded a 2-year Young Investigator Grant from the National Kidney Foundation.
Dr. John Neff was recently appointed to be a member of a Technical Advisory Panel (TAC) for the National Quality Forum (NQF) project on Priorities, Goals, and a Measurement Framework: Efficiency and Episodes of Care.
Anne M. Stevens, MD, PhD, Pediatric Rheumatology: Arthritis Foundation Investigator's Award granted for Maternal Microchimerism in Pediatric Systemic Lupus Erythematosus (SLE)
Bonnie Ramsey, MD received the 2007 Alvin Thompson Award given by the Northwest Association for Biomedical Research on May 15, 2007.
Linda Quan, MD, has been appointed to the American Red Cross Advisory Council on First Aid, Aquatics, Safety and Preparedness.
Sandra Juul, MD, PhD, was selected to serve on the Council on Research and Graduate Education for a three year term.
Richard Shugerman, MD, was selected to serve on the Council on Appointments and Promotions for a three year term.
Kevin Urdahl was approved for funding for $36,896 for his proposal “Induction of T regulatory cells that suppress immunity to tuberculosis by non-tuberculosis mycobacteria”.
Ian Glass and Daniel Doherty were approved for funding for $37,500 for his proposal "Joubert syndrome gene identification using a combination of SNP genotyping and global expression profiling methods".
FACULTY PUBLICATIONS AND PRESENTATIONS
Dr. YaeJean Kim, visiting post-doctoral fellow in Infectious Disease, working with Dr. Janet Englund at Children’s Hospital and Dr. Michael Boeckh at FHCRC:
Kim YJ, Boeckh M, Englund JA. Community respiratory virus infections in immunocompromised patients: hematopoietic stem cell and solid organ transplant recipients, and individuals with human immunodeficiency virus infection. Semin Respir Crit Care Med. 2007 Apr;28(2):222-42.
Kim YJ, Dale JK, Noel P, Brown MR, Nutman TB, Straus SE, Klion AD. Eosinophilia is associated with a higher mortality rate among patients with autoimmune lymphoproliferative syndrome. Am J Hematol. 2007 Jul;82(7):615-24.
Jamie Feinstein, MD, Pediatric Intern:
C Feudtner, JA Feinstein, M Satchell, H Zhao, TI Kang. Shifting place of death among children with complex chronic conditions in the US, 1989-2003. JAMA June 27, 2007.
Drs. Ikuyo Yamaguchi, Jesus M. Lopez-Guisa, Daryl M. Okamura, and Allison A. Eddy: Endogenous urokinase lacks antifibrotic activity during progressive renal injury. Am J Physiol Renal Physiol. 2007 Jul;293(1):F12-9. Epub 2007 Mar 13. PMID: 17356128 [PubMed - in process]
Anne M. Stevens, MD, PhD, Pediatric Rheumatology:
1. Nelson, JL, Gillespie KM, Lambert NC, Stevens AM, Loubiere LS, Rutledge JC, Leisenring WM, Erickson TD, Yan, Z, Mullarkey ME, Boespflug ND, Bingley PJ, Gale EAM (2007) Maternal microchimerism in peripheral blood in type 1 diabetes and pancreatic islet beta cell microchimerism. Proc Nat Acad Sci 104(5):1637-1642.
2. Adams, KM; Lucas, J; Kapur, RP; Stevens, AM (2007) LPS Induces Translocation of TLR4 in Amniotic Epithelium. Placenta 28(5-6):477-81.
Lenna L. Liu, MD, MPH and Cate Pihoker, MD:
Incidence of Diabetes in Youth in the United States. The Writing Group for the SEARCH for Diabetes in Youth Study Group* JAMA, June 27, 2007—Vol 297, No. 24
Arts HH*, Doherty D*, van Beersum SEC, Parisi MA, Letteboer SJF, Gorden NT, Peters TA, Märker T, Voesenek K, Kartono A, Ozyurek H, Farin FM, Kroes HY, Wolfrum U, Brunner HG, Cremers FPM, Glass IA, Knoers NVAM, Roepman R. Mutations in the gene encoding the basal body protein RPGRIP1L, a novel nephrocystin-4 interactor, cause Joubert syndrome. Nature Genetics (2007) 39(7):882-8. *These authors contributed equally to this work. Nature Genetics also included a "News and Views" on this paper.
Kristie Bjornson, Ross Hays, Cathy Graubert, Robert Price, Francine Won, John F. McLaughlin and Morty Cohen. Botulinum Toxin for Spasticity in Children With Cerebral Palsy: A Comprehensive Evaluation. Pediatrics 2007;120;49-58
D'Argenio DA, Wu M, Hoffman LR, Kulasekara HD, Deziel E, Smith EE, Nguyen H, Ernst RK, Larson Freeman TJ, Spencer DH, Brittnacher M, Hayden HS, Selgrade S, Klausen M, Goodlett DR, Burns JL, Ramsey BW, Miller SI. Growth phenotypes of Pseudomonas aeruginosa lasR mutants adapted to the airways of cystic fibrosis patients. Mol Microbiol. 2007. 64(2):512-33.
Hoffman, LR; D’Argenio, DA; Bader, MW; Miller, SI. Microbial recognition of antibiotics: Ecological, physiological, and therapeutic implications. Microbe. 2007. 2(4):175-182.
Gibson RL, Emerson J, Mayer-Hamblett N, Burns JL, McNamara, Accurso FJ, Konstan MW, Chatfield BA, Retsch-Bogart G, Waltz DA, Acton J, Zeitlin P, Hiatt P, Moss R, William J, Ramsey BW, Inhaled Tobramycin in Young Children Study Group and the Cystic Fibrosis Foundation Therapeutics Development Network. Duration of treatment effect after tobramycin solution for inhalation in young children with cystic fibrosis. Pediatr Pulmonol 2007;42(7):610-23.
Hoffman LR, Deziel E, D'Argenio DA, Lepine F, Emerson J, McNamara S, Gibson RL, Ramsey BW, Miller SI. Selection for Staphylococcus aureus small-colony variants due to growth in the presence of Pseudomonas aeruginosa. Proc Natl Acad Sci U S A 2006;103(52):19890-5.
Goss CH, Mayer-Hamblett N, Kronmal RA, Williams J, Ramsey BW. Laboratory parameter profiles among patients with cystic fibrosis. J Cyst Fibros 2007;6(2):117-23.
Deterding RR, Lavange LM, Engels JM, Mathews DW, Coquillette SJ, Brody AS, Millard SP, Ramsey BW. Phase 2 randomized safety and efficacy trial of nebulized Denufosol Tetrasodium in cystic fibrosis. Am J Respir Crit Care Med 2007 April 19; [Epub ahead of print].
MA Tablizo, P Jacinto, D Parsley, ML Chen, R Ramanathan, TG Keens. Supine sleeping position does not cause clinical aspiration in neonates in hospital newborn nurseries. Arch Pediatr Adolesc Med. 2007, 161: 507-510.
Symons JM, Annabelle NC, Somers MJG, Baum MA, Bunchman TE, Benfield MR, Brophy PD, Blowey D, Fortenberry JD, Chand D, Flores FX, Hackbarth R, Alexander SR, Mahan J, McBryde KD, Goldstein SL. Demographic characteristics of pediatric continuous renal replacement therapy: A report of the prospective pediatric continuous renal replacement therapy registry. Clinical Journal of the American Society of Nephrology 2:732-738, 2007.
Warady BA, Feneberg R, Verrina E, Flynn JT, Müller-Wiefel DE, Besbas N, Zurowska A, Aksu N, Fischbach M, Sojo E, Donmez O, Sever L, Sirin A, Alexander SR, Schaefer F. Peritonitis in children who receive long-term peritoneal dialysis: A prospective evaluation of therapeutic guidelines. Journal of the American Society of Nephrology 18: 2172-2179, 2007.
Buroker NE, Young ME, Wei C, Serikawa K, Ge M, Ning XH, Portman MA. The dominant negative thyroid hormone receptor beta-mutant {Delta}337T alters PPAR{alpha} signaling in heart. Am J Physiol Endocrinol Metab. 2007 Feb;292(2):E453-60.
Ning XH, Chen SH, Buroker NE, Xu CS, Li FR, Li SP, Song DS, Ge M, Hyyti OM, Zhang M, Portman MA. Short-cycle hypoxia in the intact heart: hypoxia-inducible factor 1alpha signaling and the relationship to injury threshold. Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H333-41.
Batra M, Heike CL, Phillips RC, Weiss NS. Geographic and occupational risk factors for ventricular septal defects: Washington State, 1987-2003. Arch Pediatr Adolesc Med 2007; 161: 89-95.
Chabra S. Letter to the Editor: Gastroschisis: brief early history. J Perinat Med 2007 July 2
McPherson RJ, Juul SE. High-dose erythropoietin inhibits apoptosis and stimulates proliferation in neonatal rat intestine. Growth Horm IGF Res 2007; July 12
Ngai AC, Mondares RL, Mayock DE, Gleason CA. Fetal alcohol exposure alters cerebrovascular reactivity to vasoactive intestinal peptide in adult sheep. Neonatology 2007; 93: 45-51
Konduri GG, Vohr B, Robertson C, Sokol GM, Solimano A, Singer J, Ehrenkranz RA, Singhal N, Wright LL, Van Meurs K, Stork, E, Kirpalani H, Peliowski A, Johnson Y, for the Neonatal Inhaled Nitric Oxide Study Group (Mayock DE - Site Investigator). Early inhaled nitric oxide therapy for term and near-term newborn infants with hypoxic respiratory failure: neurodevelopmental follow-up. J Pediatr 2007; 150: 235-240.
Evans JG, Chavez-Rueda KA, Eddaoudi A, Meyer-Bahlburg A, Rawlings DJ, Ehrenstein MR, Mauri C. Novel suppressive function of transitional 2 B cells in experimental arthritis. (2007) J Immunol 178(12):7868-7878.
Soren Gantt, Avinash K. Shetty, Kristy D. Seidel, Kuda Matasa, Georgina Musingwini, Godfrey Woelk, Lynn S. Zijenah, David A. Katzenstein, and Lisa M. Frenkel. Laboratory Indicators of Mastitis Are Not Associated with Elevated HIV-1 DNA Loads or Predictive of HIV-1 RNA Loads in Breast Milk. Journal JID 2007:196 (15 August)
Guina T*, Radulovic D, Bahrami AJ, Bolton DL, Rohmer L, Jones-Isaac KA, Chen J, Gallagher LA, Gallis B, Ryu S, Taylor GK, Brittnacher MJ, Manoil C, Goodlett DR. MglA regulates Francisella tularensis subsp. novicida response to starvation and oxidative stress. J Bacteriol. in press.
Rohmer L, Fong C, Abmayr S, Wasnick M, Larson Freeman TJ, Radey M, Guina T, Svensson K et al. (27 more authors) (2007) Comparison of Francisella tularensis genomes reveals evolutionary events associated with the emergence of human-pathogenic strains. Genome Biol. in press.
Weissman SJ, Beskhlebnaya V, Chesnokova V, Chattopadhyay S, Stamm WE, Hooton TM, Sokurenko EV (2007). Differential Stability and Trade-Off Effects of Pathoadaptive Mutations in the Escherichia coli FimH Adhesin. Infect Immun;75(7):3548-55.
Jane Hitti, MD; Janet Andersen, ScD; Grace McComsey, MD; Tun Liu, MS; Ann Melvin, MD; Laura Smith, BS; Alice Stek, MD;Judith Aberg, MD; Andrew Hull, MD; Beverly Alston-Smith, MD; D. Heather Watts, MD; Elizabeth Livingston, MD; for the AIDS Clinical Trials Group 5084 Study Team. Protease inhibitor–based antiretroviral therapy and glucose tolerance in pregnancy: AIDS Clinical Trials Group A5084. Am J Obstet Gynecol 2007;196;331.e1-331.e7.
Deepti Gupta, Dekey Lhewa, R. Viswanath, S. Mini Jacob, S. Parameshwari, R. Radhakrishnan, Kristy Seidel, Lisa M. Frenkel, NM Samuel, and Ann J. Melvin. Effectiveness of antenatal group HIV voluntary counseling and testing services in rural India. AIDS Education and Prevention, 19(3), 187–197, 2007
HK Blume, MD, MPH, CM Loch, PhD, MPH, CI Li, MD, PhD. Neonatal Encephalopathy and Socioeconomic Status: population-based case-control study. Arch Pediatr Adolesc Med July 2007.
*Please let us know of your latest publications, awards, and honors by emailing Brooke Freed (brooke.freed@seattlechildrens.org).