University of Washington School of Medicine
Seattle Children's
Department of Pediatrics Newsletter

DATE : 2009-11-20

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Items to be covered in this edition:

  1. Important Dates
  2. Welcome to New Faculty & Changes in Current Faculty
  3. New Rheumatology-Dermatology Clinic
  4. New WWAMI Pediatric Site
  5. Faculty News
  6. Faculty Publications and Presentations

top I. IMPORTANT DATES

December 17, 2009: Seminar: “Development of a Clinical and Translational Kidney Research Institute.” G1026 and broadcast to Soundgarden, 12:00-1:30pm. Dr. Jonathan Himmelfarb is Director of the Kidney Research Institute, Professor of Medicine, and Joseph W. Eschbach MD Endowed Chair in Kidney Research at UW. Dr. Himmelfarb will explore the development and importance of the Kidney Research Institute and discuss the exciting research taking place there. The Kidney Research Institute is a collaboration between Northwest Kidney Centers and UW Medicine and is focused on developing early detection, prevention and treatment of kidney disease and its complications. Presented by The Center for Clinical and Translational Research Seminar Series. Contact Charla Jones for more information: cctr@seattlechildrens.org or 884-7469.

March 1, 2010: Department of Pediatrics Faculty meeting. Wright Auditorium, 5:15-8:00 PM. As we begin preparation for next year's Faculty meetings, we would appreciate hearing what topics you would like to have considered for presentation at the evening meetings. We also would like to learn of any specific faculty development topics that would be useful to you. Please send ideas to Diane Wade (dmw@u.washington.edu).

March 26, 2010: 31st Annual Duncan Seminar: Maximizing Mobility through Adaptation and Innovation. Wright Auditorium. Mobility enables us to participate in all aspects of life. Children and youth with mobility issues are presented with unique challenges in our society. This one-day conference explores the science, therapies and technologies that support the dreams of children and their families. Register online after 1/15/10 at seattlechildrens.org/education/outreach/

April 30, 2010: Fellows’ Research Day. Seattle Children’s Research Institute, Sound Garden conference room. Keynote speaker: Gabriel Haddad, MD, Professor of Pediatrics and Neuroscience and Chair, Department of Pediatrics, University of California San Diego, Physician-in-Chief, Rady Children’s Hospital San Diego. Abstract submission information forthcoming.

top II. WELCOME TO NEW FACULTY & CHANGES IN CURRENT FACULTY

Name

Rank

Division

Brandy Hattendorf, MD

Assistant Professor

Cardiology

Dennis Lindell, PhD

Assistant Professor

Immunology

Mark Majesky, PhD

Professor

Cardiology/Center for Tissue and Cell Sciences

Changes in Current Faculty Appointments

Tina Albertson, MD, PhD

Acting Assistant Professor

Hem/Onc

top III. NEW RHEUMATOLOGY-DERMATOLOGY CLINIC

Drs. Sarah Ringold and Heather Brandling-Bennett have started a bimonthly combined Rheumatology-Dermatology clinic to see patients who may benefit from seeing providers in both specialties, including those with linear or other localized scleroderma, psoriasis with psoriatic arthritis, dermatomyositis, lupus erythematosus and other connective tissue diseases with extensive skin involvement. The clinic will be once a month on Monday afternoons.

top IV. NEW WWAMI PEDIATRIC SITE IN 2010

There is a new medical student site in Jackson, WY that will begin to take students starting July 2010. Dr. Curt Bennett, Director, Pediatric WWAMI Program, said, “We are very pleased to add Jackson, Wyoming, Pediatrics to our WWAMI group. It will be our 12th site outside of Seattle, which has become necessary as the class size has grown to well over 200.” The site director is Dr. James Little.

top V. FACULTY NEWS

Congratulations to Leslie Walker, MD, who was elected as the Society of Adolescent Medicine (SAM) President-Elect in 2010, and SAM President in 2011, and to Joseph Flynn, MD, was elected President-elect of the American Society of Pediatric Nephrology, effective as of May, 2010!

Dan Doherty, MD, PhD, was recently appointed Chair of the Scientific Advisory Board for the Joubert Syndrome and Related Disorders Foundation (JSRDF), the international family support group for Joubert syndrome.

Thank you to faculty senators for completing your terms this fall: Drs. Doug Diekema, Lisa Frenkel, Linda Quan, Michael Cunningham, Sandra Juul, Michael Bender.

The Rheumatology Clinic received the August 2009 Service Quality Award for being at or below goal on all 3 ART questions and having the most improved composite scores on the Family Experience Survey.

Lisa Cranmer, MD, Pediatric Resident, received at Resident Research Grant from the AAP for her research project entitled, “Latent TB infection among HIV-1 exposed infants”.

Laura Richardson, MD, received an R01 entitled “Adolescent Collaborative Care Treatment for Depression.” It is $2.1 million dollars over 4 years to evaluate the effect of a health services intervention to improve treatment and outcomes for depressed adolescents who are seen in primary care settings.

Colleen Delaney, MD, received a new NIH award, CTRIP: Notch-Mediated Expansion of Cord Blood Progenitors for Stem Cell Transplant. Total award is $3,470,154. 9/30/09-8/31/11.

Timothy Rose, PhD, co-Principal Investigator, in collaboration with Micronics, Inc, Redmond, WA, received Phase I funding of $444,080 within the Small Business Technology Transfer (STTR) program, to develop a “Point-of-Care molecular method for detection of known and emerging respiratory viruses (R43-AI084851)

Tim is also the PI on the following:
NIH ARRA Supplement of $302,137 on R24 RR021346 “CODEHOPs: Unique Web-based technology for gene discovery” to further develop CODEHOP-based PCR assays to detect new and emerging members of the influenza virus family and translate these into point-of-care microfluidics diagnostic tools.

NIH ARRA Supplement of $249,713 on R24 RR023343 “Herpesvirus latency and reactivation in macaque models of human disease” to further develop Luminex-based serological assays to diagnose and characterize herpesvirus infections.

top VI. FACULTY PUBLICATIONS AND PRESENTATIONS

Ken Feldman, MD: Toward instituting a chaperone policy in outpatient pediatric clinics. Child Abuse and Neglect 2009;33:709-716. Feldman KW, Jenkins C, Laney T, Seidel K.

Catherine Karr, MD, MS, PhD: Influence of Ambient Air Pollutant Sources on Clinical Encounters for Infant Bronchiolitis Catherine J. Karr, Paul A. Demers, Mieke W. Koehoorn, Cornel C. Lencar, Lillian Tamburic, and Michael Brauer. Am. J. Respir. Crit. Care Med. 2009;180 995-1001.

Michael Bamshad, MD: Exome sequencing identifies the cause of a mendelian disorder. Sarah B Ng, Kati J Buckingham, Choli Lee, Abigail W Bigham, Holly K Tabor, Karin M Dent, Chad D Huff, Paul T Shannon, Ethylin Wang Jabs, Deborah A Nickerson, Jay Shendure & Michael J Bamshad.

Doug Diekema, MD: Ethical Issues in Research Involving Infants. Seminars in Perinatology 2009; 33:364-371. Diekema, DS.

Elena Shephard, MD, MPH and Eileen Klein, MD, MPH: Disaster preparedness: Are retired physicians willing to help? Disaster Medicine September/October 2009 Vol 4 No 5 Pages 279-286. Elena Shephard, MD, MPH, Eileen Klein, MD, MPH, Kathryn Koelemay, MD, MPH, Jack Thompson, MSW.

Linda Quan, MD, was invited speaker to the Interagency Working Group for Visitor Safety on Federal Lands: (National Park Service, Bureau of Land Management, Army Corps of Engineers, National Forest Service, Bureau of Reclamation) in WA DC on Preventing drowning in open waters.

Karen F. Murray, MD, has been asked to speak at PAS on careers in Pediatric Gastroenterology and Hepatology.

Cora Collette Breuner, MD, MPH: Randomized Controlled Clinical Trial of Yoga in the Treatment of Eating Disorders. T. Rain Carei, Amber L. Fyfe-Johnson, Cora C. Breuner, Margaret A. Brown. Journal of Adolescent Health - 03 November 2009

Drs. David Shurtleff, Janet Englund, and Ed Marcuse: Haemophilus influenzae and Streptococcus pneumoniae Infections in Children with Cerebrospinal Fluid Shunts. Pediatr Neurosurg 2009;45:276-80. Shurtleff DB, Loeser J D, Avellino AM, Duguay SB, Englund JA, Marcuse EK, MD, Peterson D

Drs. Janet Englund and Danielle Zerr: MMWR Dispatch – Oseltamivir-Resistant Novel Influenza A (H1N1) Virus Infection in Two Immunosuppressed Patients-Seattle, WA 2009. MMWR 58:1-3 (Aug. 14, 2009). Englund J, Zerr D, Heath J, Pergam S, Kuypers J, Yager J, Boeckh M, Mattson D, Whittington N, Whimbey, Duchin J, Uyeki T, Dyde V, Okomo-Adhiambo M, Sheu T, Trujillo A, Klimov A, Gubareva L, Kay M.

Jeffrey G Demain, MD, Clinical Associate Professor, Director, Allergy, Asthma & Immunology Center of Alaska: Increasing insect reactions in Alaska: Is this related to climate change. Allergy Asthma Proc 30:238-234, 2009. Demain J G, Gessner BD, McLaughlin JB, Sikes DS, Foote JT.

Helén L. Dichek, MD:

  1. TGF-[beta]1 limits plaque growth, stabilizes plaque structure, and prevents aortic dilation in apoliporotiein E-null mice. Arterioscler Thromb Vasc Biol. (2009) 29:1251-7. Epub 2009 Mar 26. Frutkin AD, Otsuka G, Stempien-Otero A, Sesti C, Du, L., Jaffe M, Dichek HL, Pennington CJ, Edwards DR, Nieves-Cintron M, Minter D, Preusch M, HU JH, Marie JC, Dichek DA.
  2. Level of macrophage uPA expression is an important determinant of atherosclerotic lesion growth in Apoe-/- mice Arterioscler Thromb Vasc Biol. 29:1737-1744. Krishnan, R., Kremen, M., Hu, J. H, Emery, I., Farris, S. D., Slezicki, K.I., Chu, T., Du, L., Dichek, H. L. Dichek, D.A. (2009)

Edward J. Novotny, Jr., MD, Head, Epilepsy Program, Neurology:

  1. Spatial distribution of intracranially recorded spikes in medial and lateral temporal epilepsies. Goncharova II, Zaveri HP, Duckrow RB, Novotny EJ, Spencer SS. Epilepsia. 2009 Aug 8.
  2. Centrotemporal sharp wave EEG trait in rolandic epilepsy maps to Elongator Protein Complex 4 (ELP4). Strug LJ, Clarke T, Chiang T, Chien M, Baskurt Z, Li W, Dorfman R, Bali B, Wirrell E, Kugler SL, Mandelbaum DE, Wolf SM, McGoldrick P, Hardison H, Novotny EJ, Ju J, Greenberg DA, Russo JJ, Pal DK. Eur J Hum Genet. 2009 Sep;17(9):1171-81
  3. A decrease in EEG energy accompanies anti-epileptic drug taper during intracranial monitoring. Zaveri HP, Pincus SM, Goncharova II, Novotny EJ, Duckrow RB, Spencer DD, Spencer SS. Epilepsy Res. 2009 Oct;86(2-3):153-62

Timothy Rose, PhD:

  1. iCODEHOP: a new interactive program for designing COnsensus-DEgenerate Hybrid Oligonucleotide Primers from multiply aligned protein sequences. Nucleic Acids Res. 37 (Web Server Issue): W222-8. Boyce R, Chilana P, Rose TM.
  2. Consensus-degenerate hybrid oligonucleotide primers (CODEHOPs) for the detection of novel viruses in non-human primates. Methods 49, 32-41. Staheli, JP, Ryan JT, Bruce AG, Boyce R, and Rose TM.
  3. The ORF59 DNA polymerase processivity factor homologs of Old World primate RV2 rhadinoviruses are highly conserved nuclear antigens expressed in differentiated epithelium in infected macaques. Virology Journal (In Press). Bruce AG, Bakke AM, Gravett C, DeMaster LK, Bielefeldt-Ohmann H, Burnside KL, and Rose TM (2009)

Joseph T. Flynn, MD:

  1. Pathophysiology of hypertension. In: Avner E, Harmon W, Niaudet P, Yoshikawa N, eds. Pediatric Nephrology, 6th ed. Philadelphia, PA: Lippincott Williams and Wilkins, 2009, pp. 1485–1518. Yamaguchi I, Flynn JT.
  2. Hypertension, growth and skeletal maturation in the young: A new look at an old idea (editorial). Hypertension, DOI: 10.1161/HYPERTENSIONAHA.109.142067, 2009. Flynn JT.
  3. Masked Hypertension Associates with Left Ventricular Hypertrophy in Children with CKD. J Am Soc Nephrol 2010; doi: 10.1681/ASN.2009060609. Mitsnefes M, Flynn J, Cohn S, Samuels J, Blydt-Hansen T, Saland J, Kimball T, Furth S, Warady B.

Dan Doherty, MD, PhD:

  1. Joubert Syndrome: Insights Into Brain Development, Cilium Biology, and Complex Disease. Seminars in Pediatric Neurology (2009) 16(3):143-54. PMID: 19778711 Doherty D.
  2. OFD1 is mutated in X-linked Joubert syndrome and interacts with LCA5-encoded lebercilin. American Journal of Human Genetics (2009) 85(4):465-81. PMID: 19800048. Coene K, Roepman R, Doherty D, Afroze B, Kroes H, Letteboer S, Ngu L, Budny B, van Wijk E, Gorden NT, Azhimi M, Thauvin-Robinet C, Veltman J, Boink M, Kleefstra T, Cremers F, van Bokhoven H, de Brouwer A.
  3. Identification of TRAPPC9, which encodes the NIK and IKK-β binding protein (NIBP), in Non-Syndromic Autosomal Recessive Mental Retardation. American Journal of Human Genetics (in press). Mir A, Kaufman L, Noor A, Jamil T, Rafiq MA, Weksberg R, Nasr T, Naeem F, Azam M, Kahrizi K, Doherty D, Barkovich AJ, Najmabadi H, Ayub M, Vincent JB.

Sihoun Hahn, MD, PhD:

  1. Next generation sequence analysis for mitochondrial disorders. Genome Med. 2009 Oct 23;1(10):100. [Epub ahead of print]. Vasta V, Ng SB, Turner EH, Shendure J, Hahn SH.
  2. Simultaneous determination of alpha-aminoadipic semialdehyde, piperideine-6-carboxylate and pipecolic acid by LC-MS/MS for pyridoxine-dependent seizures and folinic acid-responsive seizures. J Neurosci Methods. 2009 Oct 30;184(1):136-41. Sadilkova K, Gospe SM Jr, Hahn SH.

Drs. Sihoun Hahn and J. Lawrence Merritt II: A cognitively normal PDH-deficient 18-year-old man carrying the R263G mutation in the PDHA1 gene. J Inherit Metab Dis. 2009 Jul 29. [Epub ahead of print]. Bachmann-Gagescu R, Merritt JL, Hahn SH.

Drs. Mohamed Oukka, Hans Ochs, and Troy Torgerson: TH17 cells and regulatory T cells in primary immunodeficiency diseases. J Allergy Clin Immunol 2009; 123:977-983; quiz 984-985. PMID: 19410687. Ochs HD, Oukka M, Torgerson TR.

Drs. Hans Ochs and Troy Torgerson:

  1. Comel-Netherton syndrome defined as primary immunodeficiency. J Allergy Clin Immunol 2009;124(3):536-543. PMID: 19683336. Renner ED, Hartl D, Rylaarsdam S, Young ML, Monaco-Shawver L, Kleiner G, Markert ML, Stiehm ER, Belohradsky BH, Upton MP, Torgerson TR, Orange JS, Ochs HD.
  2. FOXP3 inhibits activation-induced NFAT2 expression in T cells thereby limiting effector cytokine expression. J Immunol 2009;183(2):907-915.PMID: 19564342. Torgerson TR, Genin A, Chen C, Zhang M, Zhou B, Anover-Sombke S, Frank MB, Dozmorov I, Ocheltree E, Kulmala P, Centola M, Ochs HD, Wells AD, Cron RQ.

Drs. Hans Ochs, Troy Torgerson, Carol Miao, David Rawlings: CD4+FOXP3+ regulatory T cells confer long-term regulation of factor VIII-specific immune responses in plasmid-mediated gene therapy treated hemophilia mice. Blood 2009. [Epub ahead of print] PMID: 19713458. Miao CH, Harmeling BR, Ziegler SF, Yen BC, Torgerson TR, Chen L, Yau RJ, Peng B, Thompson AR, Ochs HD, Rawlings DJ.

Drs. Hans Ochs and David Rawlings: Wiskott-Aldrich syndrome protein is required for homeostasis and function of invariant NKT cells. J Immunol 2009;182(12):7370-7380. PMID: 19494259. Astrakhan A, Ochs HD, Rawlings DJ.

Hans Ochs, MD:

  1. Immune responses in adult female volunteers during bed-rest model of space flight: antibodies and cytokines. J Allergy Clin Immunol 2009. [Epub ahead of print] PMID: 19232702. Shearer WT, Ochs HD, Bang-Ning L, Cohen E, Reuben JM, Cheng I, Thompson B, Butel J, Blancher A, Abbal M, Aviles H, Sonnenfeld G.
  2. FBP17 mediates a common molecular step in the formation of podosomes and phagocytic cups in macrophages. J Biol Chem 2009. PMID: 19155218. Tsuboi S, Takada H, Hara T, Mochizuki N, Funyu T, Saitoh H, Terayama Y, Yamaya K, Ohyama C, Nonoyama S, Ochs HD.
  3. Immunomodulatory effects of mixed hematopoietic chimerism: immune tolerance in canine model of lung transplantation. Am J Transplant 2009;9(5):1037-1047. PMID: 19422333. Nash RA, Yunosov M, Abrams K, Hwang B, Castilla-Llorente C, Chen P, Farivar AS, Georges GE, Hackman RC, Lamm WJ, Lesnikova M, Ochs HD, Randolph-Habecker J, Ziegler SF, Storb R, Storer B, Madtes DK, Glenny R, Mulligan MS.

*Please let us know of your latest publications, awards, and honors by emailing Brooke Freed.