Training and direction in research begin. This includes discussions of research topics/areas of interest and identifying a research mentor. The first-year fellow can rotate through basic laboratories within the University of Washington system and the basic science laboratories of the Cystic Fibrosis Research Development Program. Specifically, the laboratories that are performing lung cellular and molecular biology at the University of Washington provide excellent research opportunities for trainees. An active clinical research program in cystic fibrosis, including the Cystic Fibrosis Foundation–funded Therapeutics Development Center, provides trainees with opportunities to participate in cystic fibrosis clinical trials. There are also opportunities to participate in clinical studies in other diseases, such as asthma.
Examples of current research interests among divisional and non-divisional faculty include asthma, non-invasive monitoring of lower airway inflammation in wheezing infants, RSV preventive therapies, clinical investigation of novel new therapies and outcome measures in cystic fibrosis (i.e., raised-volume infant lung function tests, hypertonic-saline induced sputum), early anti-pseudomonal treatment in young children with cystic fibrosis, basic research on pseudomonas-host interactions in the CF airway and gene therapy related to cystic fibrosis.
Devoted primarily to research efforts, which can be clinical and/or basic science in nature. Fellows who are interested in clinical research are encouraged to enroll in the University of Washington School of Public Health to pursue a Master of Public Health degree. Each fellow is expected to complete one research project during the second year that can be presented at a national meeting and submitted for publication. Clinical activities in the second year include two months on the pulmonary service at Seattle Children's and weekly participation in Chest, Sleep, Asthma and Cystic Fibrosis Clinics (half day per week, total). We emphasize continuity of care and encourage fellows to manage a core group of patients identified from the first year.
Devoted to research, further clinical training and team leadership skills. A goal is for the trainee to work with faculty to obtain research funding for an individual research project during the third year of training. There is ongoing longitudinal participation in Chest, Sleep, Asthma and Cystic Fibrosis Clinics (half day per week) and one month in a supervisory role on the pulmonary service at Seattle Children's.