Department Newsletters

Department of Pediatrics Newsletter
September 19, 2011

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Items to be covered in this edition:

  1. Important Dates
  2. Welcome to New Faculty & Changes to Current Faculty
  3. Faculty News
  4. Faculty Publications and Presentations

I. IMPORTANT DATES

September 20: Center for Clinical and Translational Research External Review. 8:15AM – 12:00PM, Seattle Children’s Research Institute, Westlake Conference Room, West 8th Building. All Seattle Children’s faculty and staff are invited to attend research presentations by CCTR faculty. Questions? Contact  Brooke.Freed@seattlechildrens.org.

September 21: Deadline for the Department of Pediatrics Task Force on Diversity  Survey. We are slightly over 50% participation, and would like as much feedback as possible for the survey to be meaningful.  Please complete this survey to help us improve our understanding of the Department of Pediatrics and the faculty diversity we currently have in the Department. We appreciate your support. Questions? Contact  Leslie.Walker@seattlechildrens.org

September 22: Dr. Deisher Lecture Series – Guest Speaker: Dr. Charles E. Irwin, Jr.
- Grand Rounds: 8:00-9:00AM, Wright Auditorium at Seattle Children’s Hospital. “Adolescent Health: Can the Delivery of Preventive Services Be Improved.” Charles Irwin, MD.
- Brown-Bag Lunch with Dr. Irwin: 11:30AM-1:30PM. Board Room at Seattle Children’s Hospital. The Division of Adolescent Medicine invites you to an informal meet and greet/brown-bag lunch. Come listen to Dr. Irwin speak about “Getting Your Manuscript Published in the Journal of Adolescent Health” and don’t forget to bring your lunch! Contact  Richard.Augastino@seattlechildrens.org

September 22–23: Ethical Considerations in Research Collaborations. Meany Hall at UW. Sponsored by the UW Office of Research, ITHS, FHCRC, and Seattle Children’s and funded by the Office of Research Integrity, of US Health and Human Services, nationally recognized speakers from across the country will gather to discuss ethical challenges in three areas of research collaborations: University-Industry Collaboration, Researcher to Researcher Collaboration, and Collaboration in the International Arena. Registration available on–site for $200. Questions? Contact oriconf@u.washington.edu

September 27: Megan Moreno, MD, Lecture. 2PM–3PM in Wright Auditorium.  “Social Networking Sites and Adolescent Health: New Opportunities and New Challenges.”  Questions? Contact  Richard.Augastino@seattlechildrens.org.

September 28: Professors and Associate Professors Meeting to discuss promotions. 8:00-9:00AM, Wright Auditorium at Seattle Children’s Hospital. Questions? Contact  diane.wade@seattlechildrens.org

October 3: Integrated Health Seed Grants: Mandatory letters of intent are Due October 3, 2011.  Applications due November 7, 2011.  One-year, $25,000 research awards designed to promote research across the female life cycle, encourage cross-disciplinary research collaborations and promote development of junior investigators.  For details on how to apply www.globalwach.org/seed-grants.Questions?  Contact  pkohler2@uw.edu

October 15: Application deadline for the Center for Clinical and Translational Research Clinical Research Scholars Program (CRSP), a mentored research career development program. Questions? Contact Kelsey Heriot, CRSP Program Coordinator (crsp@seattlechildrens.org)

October 18: Department Faculty Meeting. 5:15-7:30PM, Wright Auditorium at Seattle Children’s Hospital. More details forthcoming. Questions? Contact diane.wade@seattlechildrens.org.

II.             WELCOME TO NEW FACULTY & CHANGES TO CURRENT FACULTY

II. FACULTY PROMOTIONS (EFFECTIVE JULY 1, 2011)

Name Rank Division
Kelly Faucette, MD Clinical Professor- FTCF Hospital Medicine
Aarti Bhat, MD Assistant Professor Cardiology
Reid Farris, MD Assistant Professor Critical Care
Sabrina Law, MD Assistant Professor Cardiology
Amy Tsai, MD Assistant Professor GI & Hepatology
Gwen Glew, MD, MPH Clinical Assistant Professor- FTCF Developmental Medicine
Rebecca Partridge, MD Clinical Assistant Professor- FTCF Emergency Medicine
Frances Prekker, MD Clinical Assistant Professor- FTCF Hospital Medicine
Whitney Waite, MD Clinical Instructor- FTCF Hospital Medicine

Dennis Christie, MD, has stepped down after serving as Division Chief of Pediatric Gastroenterology and Hepatology for 22 years. He will remain active as a clinician and educator. We welcome Karen Murray, MD, Professor of Pediatrics, as the new Chief of this division.

Dr. Jane Burns, Professor of Pediatrics, has been the Division Chief of Pediatric Infectious Disease for the past four years and stepped down to return to research.  Danielle Zerr, MD, MPH, Associate Professor of Pediatrics, has agreed to fill this position as Acting Division Chief of Pediatric Infectious Disease for at least two years, and will continue to be assisted by Ann Melvin, MD, Associate Division Chief.

Tom Hansen, MD, recently joined the University of Washington Department of Bioengineering as an Adjunct faculty member.

III. FACULTY NEWS

William E. Pierson, MD, passed away on September 3, 2011 at age 77. Dr. Pierson was one of the original partners in NW Asthma and Allergy and at Springbrook Associates where he practiced pediatric allergy. During his career at the University of Washington, he was a clinical professor and co-director of the Department of Allergy at Seattle Children’s. Please see his attached obituary.

Sihoun Hahn, MD, PhD, was invited to join UpToDate as the new Section Editor for the Pediatric Genetics section.

Christian Roth, MD, was recognized for authoring a top 10 cited article in Metabolism: Clinical and Experimental.

Ed Marcuse, was chosen by Every Child by Two, a national immunization advocacy organization, to be the recipient of the Every Child By Two Martin H. Smith, MD Award. The awards will be presented October 11, 2011 at The Smithsonian American Art Museum and National Portrait Gallery.

As part of a multicenter consortium to develop an anatomic and developmental ontology of the human craniofacial complex, Drs. Carrie Heike, Timothy Cox, and Michael Cunningham joined Linda Shapiro (PI, UW Computer Science and Engineering) and Jim Brinkley (Department of Biological Structure) and were awarded a three year 2 million dollar grant from the National Institute of Dental and Craniofacial Research. This research will be used to provide further support to the  FaceBase Consortium.

IV. FACULTY PUBLICATIONS AND PRESENTATIONS

Daniela Luquetti, MD, PhD: Microtia-Anotia: A Global Review Of Prevalence Rates. Luquetti DV, Leoncini E, Mastroiacovo P. Birth Defects Res A Clin Mol Teratol. 2011 Jun 7. doi: 10.1002/bdra.20836. [Epub ahead of print] PubMed PMID: 21656661.

Jeffrey Demain, MD, FAAAAI, FAAP: Insect Anaphylaxis: Addressing Clinical Challenges. Tracy JM, Lewis EJ, Demain JG. Current Opinion in Allergy and Clinical Immunology 2011, 11:332–336.

Michael Bender, MD, PhD: A Functional Element Necessary For Fetal Hemoglobin Silencing. Sankaran VG, Xu J, Byron R, Greisman HA, Fisher C, Weatherall DJ, Sabath DE, Groudine M, Orkin SH, Premawardhena A, Bender MA. N Engl J Med 2011; 365:807-814 September 1, 2011.

David Suskind, MD: Nutritional Strategy For The Adolescent Patient Undergoing Bariatric Surgery: Report Of A Working Group Of The Nutrition Committee For The North American Society Of Pediatric Gastroenterology, Hepatology And Nutrition And National Association Of Children's Hospital And Related Institutions. Fullmer MA, Abrams SH, Hrovat K, Mooney L, Scheimann AO, Hillman JB, Suskind DL. J Pediatr Gastroenterol Nutr. 2011 Aug 17. [Epub ahead of print]

Drs. David Suskind, Anne Stevens, Ghassan Wahbeh, and Dennis Christie: Maternal Microchimerism In Pediatric Inflammatory Bowel Disease. Suskind DL, Kong D, Stevens AM, Wahbeh G, Christie D, Baxter-Lowe LA, Muench MO. Chimerism 2:2, 1-5; April/May/June 2011.

Drs. Dimitri Christakis and Megan Moreno (former fellow): Problematic Internet Use Among US Youth: A Systematic Review. MMoreno, LJelenchick, ECox, HYoung, DChristakis. Arch Pediatr Adolesc Med. Sept 2011.

Drs. Michelle Garrison, Paula Lozano, Dimitri Christakis: Controller Medication Use and Sleep Problems in Pediatric Asthma: A Longitudinal Case-Crossover Analysis. Arch Pediatr Adolesc Med. Sept 2011.

Drs. Nicole Mayer-Hamblett, Judy Williams, Ronald Gibson, Jane Burns, Margaret Rosenfeld, Bonnie Ramsey: Comparative Efficacy and Safety of 4 Randomized Regimens to Treat Early Pseudomonas aeruginosa Infection in Children with Cystic Fibrosis. Arch Pediatr Adolesc Med. Sept 2011.

Michael Cunningham, MD, PhD: Parameters Of Care For Craniosynostosis. McCarthy JG, Warren SM, Bernstein JM, Burnett W, Cunningham ML, Edmond JC, Figueroa AA, Kapp-Simon KA, Labow B, Peterson-Falzone S, Proctor M, Rubin M, Sze RW, Yemen T. Cleft Palate Craniofac J. 2011 Aug 17. PubMed PMID: 21848431.

Drs.Timothy Cox, Murat Maga and Michael Cunningham: Heterozygous Mutations Of FREM1 Are Associated With An Increased Risk Of Isolated Metopic Craniosynostosis In Humans And Mice. Vissers LELM, Cox TC, Maga AM, Short KM, Wiradjaja F, Janssen IM, Jehee F, Bertola D, Liu J, Yagnik G, Sekiguchi K, Kiyozumi K, van Bokhoven H, Marcelis C, Cunningham ML, Anderson PJ, Boyadjiev SA, Passos-Bueno MR, Veltman JA, Smyth I, Buckley MF, Roscioli T. 2011, PLoS Genet 7(9): e1002278. doi:10.1371/ journal.pgen.1002278

Drs. Jacqueline Starr, Carrie Heike, and Michael Cunningham: Development In Toddlers With And Without Deformational Plagiocephaly. Collett BR, Starr JR, Kartin D, Heike CL, Berg J, Cunningham ML, Speltz ML. Arch Pediatr Adolesc Med. 2011 Jul;165(7):653-8. PubMed PMID: 21727278.

Drs. Daniel Doherty and Kathy Millen. Nature Medicine News And Views: Wormless Without Wingless. Doherty D, Millen KJ. Nat Med. 2011 Jun;17(6):663-5. Comment on Nat Med. 2011 Jun;17(6):726-31. PMID: 21647144 [PubMed - indexed for MEDLINE]

Joseph Flynn, MD:

  1. Hypertension: Significance, Diagnosis And Management. Flynn JT. In: Fisher MM, Alderman EM, Kreipe RE, Rosenfeld WD, eds. Textbook of Adolescent Health Care, 3rd ed. Elk Grove Village, IL, American Academy of Pediatrics, 2011, pp. 1152-1168.
  2. Ambulatory Blood Pressure Monitoring In Children: Imperfect, Yet Essential (editorial commentary). Flynn JT. Pediatric Nephrology, DOI 10.1007/s00467-011-1984-9, 2011.

Daniel Doherty, MD, PhD:

  1. The Ciliopathy Gene cc2d2a Controls Zebrafish Photoreceptor Outer Segment Development Through A Role In Rab8-Dependent Vesicle Trafficking. Bachmann-Gagescu R, Phelps IG, Stearns G, Link BA, Brockerhoff SE, Moens CB, Doherty D. Hum Mol Genet. 2011 Aug 10. [Epub ahead of print] PubMed PMID: 21816947.
  2. Mapping the NPHP-JBTS-MKS Protein Network Reveals Ciliopathy Disease Genes And Pathways. Sang L, Miller JJ, Corbit KC, Giles RH, Brauer MJ, Otto EA, Baye LM, Wen X, Scales SJ, Kwong M, Huntzicker EG, Sfakianos MK, Sandoval W, Bazan JF, Kulkarni P, Garcia-Gonzalo FR, Seol AD, O'Toole JF, Held S, Reutter HM, Lane WS, Rafiq MA, Noor A, Ansar M, Devi AR, Sheffield VC, Slusarski DC, Vincent JB, Doherty DA, Hildebrandt F, Reiter JF, Jackson PK. Cell. 2011 May 13;145(4):513-28. PubMed PMID: 21565611.

Drs. Hans Ochs and Anne Stevens: Monitoring Serum IL-18 Levels Is Useful For Treatment Of A Patient With Systemic Juvenile Idiopathic Arthritis Complicated By Macrophage Activation Syndrome. Shigemura T, Yamazaki T, Hara Y, Ou JN, Stevens AM, Ochs HD, Koike K, Agematsu K. Pediatr Rheumatol Online J. 2011;9(1):15  PMID:21749729 PMC3155148

Drs. Hans Ochs, Troy Torgerson, and Laurie Burroughs: Long-Term Outcome And Lineage-Specific Chimerism In 194 Wiskott- Aldrich Syndrome Patients Treated By Hematopoietic Cell Transplantation Between 1980-2009: An International Collaborative Study. Moratto D, Giliani S, Bonfim C, Mazzolari E, Fischer A, Ochs HD, Cant AJ, Thrasher AJ, Cowan MJ, Albert MH, Small T, Pai SY, Haddad E, Lisa A, Hambleton S, Slatter M, Cavazzana-Calvo M, Mahlaoui N, Picard C, Torgerson TR, Burroughs L, Koliski A, Zanis Neto J, Porta F, Qasim W, Veys P, Kavanau K, Honig M, Schulz A, Friedrich W, Notarangelo LD. Blood. 2011 Jun 9. [Epub ahead of print] PMID:21659547 [PubMed - as supplied by publisher]

Hans Ochs, MD:

  1. Efficacy And Safety Of Home-Based Subcutaneous Immunoglobulin Replacement Therapy In Paediatric Patients With Primary Immunodeficiencies. Borte M, Bernatowska E, Ochs HD, Roifman CM. Clin Exp Immunol. 2011 Jun;164(3):357-364. PMCID: PMC 3087931
  2. Reduced Thymic Output, Cell Cycle Abnormalities, And Increased Apoptosis Of T Lymphocytes In Patients With Cartilage-Hair Hypoplasia. de la Fuente MA, Recher M, Rider NL, Strauss KA, Morton DH, Adair M, Bonilla FA, Ochs HD, Gelfand EW, Pessach IM, Walter JE, King A, Giliani S, Pai SY, Notarangelo LD. J Allergy Clin Immunol. 2011 May 12. PMID:21570718 [PubMed - as supplied by publisher]
  3. Indications And Safety Of Intravenous And Subcutaneous Immunoglobulin Therapy. Rezaei N, Abolhassani H, Aghamohammadi A, Ochs HD. Expert Rev Clin Immunol. 2011 May;7(3):301-316.  PMID:21595597 [PubMed - in process]
  4. Genetic Analysis Of Contiguous X-Chromosome Deletion Syndrome Encompassing The BTK And TIMM8A Genes. Arai T, Zhao M, Kanegane H, van Zelm MC, Futatani T, Yamada M, Ariga T, Ochs HD, Miyawaki T, Oh-Ishi T. J Hum Genet. 2011 Jul 14. PMID:
    21753765.
  5. Identification Of FOXP3-Negative Regulatory T-Like (CD4(+)CD25(+)CD127(Low)) Cells In Patients With Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked Syndrome. Otsubo K, Kanegane H, Kamachi Y, Kobayashi I, Tsuge I, Imaizumi M, Sasahara Y, Hayakawa A, Nozu K, Iijima K, Ito S, Horikawa R, Nagai Y, Takatsu K, Mori H, Ochs HD, Miyawaki T. Clin Immunol. 2011 Jul 12 PMID:21802372.
  6. Partial Immune Reconstitution Of X-Linked Hyper Igm Syndrome With Recombinant CD40 Ligand. Jain A, Kovacs JA, Nelson DL, Migueles SA, Pittaluga S, Fanslow W, Fan X, Wong DW, Massey J, Hornung R, Brown MR, Spinner JJ, Liu S, Davey V, Hill HA, Ochs H, Fleisher TA. Blood. 2011 Aug 12. [Epub ahead of print] PMID:21841160.