Department Newsletters

Department of Pediatrics Newsletter
May 20, 2011

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Items to be covered in this edition:

  1. Important Dates
  2. Faculty Promotions
  3. Faculty News
  4. Faculty Publications and Presentations

I. IMPORTANT DATES

May 23, 2011: Center for Child Health, Behavior and Development 2nd Annual Symposium. 8:30AM-5:00PM at the West 8th Building's 4th floor Conference Rooms, Seattle Children's Research Institute. Please RSVP to jenn.chun@seattlechildrens.org

May 26, 2011: Department Chair Grand Rounds: "The Department of Pediatrics: Serving Our Community" 8:00-9:00AM in Wright Auditorium.

June 9, 2011: Department Faculty Meeting. 5:15-7:30PM in Wright Auditorium. A social gathering with appetizers from 5:15-5:45PM will be followed by the regular meeting from 5:45-7:30PM. Questions? Contact diane.wade@seattlechildrens.org

June 10, 2011: End-of-the-year Residents' Banquet. 6:30PM at The Knights of Columbus on Capitol Hill. Please RSVP to scott.olson@seattlechildrens.org by May 31.

July 22- 23, 2011: Seventh Annual Pediatric Bioethics Conference. A two-day session at Bell Harbor International Conference Center in Seattle. Through presentations, panel discussions, and breakout sessions, leaders in the field of pediatric bioethics will discuss issues around the theme "Who's Responsible for the Children? Exploring the Boundaries of Clinical Ethics and Public Policy". Register online (http://www.regonline.com/Register/Checkin.aspx?EventID=931417) or contact kathie.kohorn@seattlechildrens.org with questions.

July 26: Annual Department of Pediatrics Faculty & Family Picnic. 6:00-8:00PM at Gas Works Park. More information to follow. Questions? Contact diane.wade@seattlechildrens.org

September 19-23, 2011: Intern Retreat. The retreat has been an integral part of intern education for the past 35 years. The interns spend this week participating in workshops to promote communication skills and professionalism. Your support during this week of education and bonding is greatly appreciated by all of the interns and faculty. Coverage will be needed for Medicine Teams, Emergency Room, Medically Complex Children, Newborn Nursery (UW) and Neonatal Intensive Care (UW). Additional details attached. Questions? Contact pam.burke@seattlechildrens.org

II. FACULTY PROMOTIONS (EFFECTIVE JULY 1, 2011)

Name Promotion Division
Cora Breuner, MD, MPH Professor Adolescent Medicine
Lenna Liu, MD, MPH Professor General Pediatrics
Rita Mangione-Smith, MD, MPH Professor General Pediatrics
Brian Saelens, PhD Professor General Pediatrics
Sherilyn Smith, MD Professor Infectious Diseases
Julian Davies, MD Clinical Professor General Pediatrics
Margaret Hood, MD Clinical Professor Hospital Medicine
Blythe Thomson, MD Clinical Professor Hematology/Oncology
Jeffrey Bartlett, MD Clinical Professor Volunteer Clinical Faculty
Jonathan Becker, MD Clinical Professor Volunteer Clinical Faculty
Ruth Conn, MD Clinical Professor Volunteer Clinical Faculty
Robert Fukura, MD Clinical Professor Volunteer Clinical Faculty
Bruce Hardy, MD Clinical Professor Volunteer Clinical Faculty
Mary Lasley, MD Clinical Professor Volunteer Clinical Faculty
Ourania Malliris, MD Clinical Professor Volunteer Clinical Faculty
Don McInturff, MD Clinical Professor Volunteer Clinical Faculty
Monica Richter, MD, PhD Clinical Professor Volunteer Clinical Faculty
Daniel Doherty, MD, PhD Associate Professor Developmental Medicine
Catherine Karr, MD, MS, PhD Associate Professor General Pediatrics
Suzan Mazor, MD Associate Professor Emergency
Mohamed Oukka, PhD Associate Professor Immunology
Lakshmi Rajagopal, PhD Associate Professor Infectious Diseases
Michael Davis, MD Clinical Associate Professor Critical Care Medicine
Anne Leavitt, MD Clinical Associate Professor Developmental Medicine
Robert Mazor, MD Clinical Associate Professor Critical Care Medicine
Carlos Villavicencio, MD Clinical Associate Professor Hospital Medicine
Stephanie Wallace, MD Clinical Associate Professor Genetic Medicine
Danae Nakoneczny, MD Clinical Assistant Professor Hospital Medicine
Matthew Allen, MD Clinical Associate Professor Volunteer Clinical Faculty
Martin Beals, Jr, MD Clinical Associate Professor Volunteer Clinical Faculty
Victoria Cartwright, MD, MS Clinical Associate Professor Volunteer Clinical Faculty
Barbara Coopes, MD Clinical Associate Professor Volunteer Clinical Faculty
Michael Crook, MD Clinical Associate Professor Volunteer Clinical Faculty
Neil Kaneshiro, MD Clinical Associate Professor Volunteer Clinical Faculty
Keith Lemmon, MD Clinical Associate Professor Volunteer Clinical Faculty
Matthew Murdoch, MD Clinical Associate Professor Volunteer Clinical Faculty
Dion Roberts, MD Clinical Associate Professor Volunteer Clinical Faculty
Charles Ryan, MD Clinical Associate Professor Volunteer Clinical Faculty
Laura Schuilz, MD Clinical Associate Professor Volunteer Clinical Faculty
Niran Al-Agba, MD Clinical Assistant Professor Volunteer Clinical Faculty
Naya Antink, MD Clinical Assistant Professor Volunteer Clinical Faculty
Brian Fulks, MD Clinical Assistant Professor Volunteer Clinical Faculty
Joyce Gilbert, MD Clinical Assistant Professor Volunteer Clinical Faculty
Aaron Grigg, MD Clinical Assistant Professor Volunteer Clinical Faculty
Mason Oltman, MD Clinical Assistant Professor Volunteer Clinical Faculty

III. FACULTY NEWS

Leslie Walker, MD, received a provisional appointment to the Institute of Medicine's (IOM) Standing Committee on Family Planning.

Matthew Giefer, MD, received the "Abstract of Distinction Award" at Digestive Disease Week in Chicago.

Drs. Rob Roskin and Christine Gleason received the "Rich Molteni Quality Improvement Award" from the medical staff.

Bruder Stapleton, MD, received the 2011 Founder's Award from the American Society of Pediatric Nephrology (ASPN). The award recognizes individuals who have made a unique and lasting contribution to the field of pediatric nephrology.

Peter Tarczy-Hornoch, MD, FACMI: Selected to serve on the Clinical Informatics Subcommittee, Academy Health Electronic Data Management Forum; The American Medical Informatics Association strategic plan pillar task force on Sharing Knowledge Through Meetings; External Advisory Board for the Harvard National Center for Biomedical Computing "Integrating Information from Bench to Bedside (i2b2)"; External Advisory Board, University of California San Diego National Center for Biomedical Computing "Integrating Data for Analysis, Anonymization and Sharing (iDASH)"; Nominations Committee, American College of Medical Informatics.

Dr. Tarczy-Hornoch has been serving as the Lead of the Health Informatics Core on the $11.6M AHRQ funded grant "Surgical Care and Outcomes Assessment Program (SCOAP) Comparative Effectiveness Research Translation Network (CERTN)." This grant focuses on integrating electronic medical record data from up to 15 sites in WA for CER research including a text mining and natural language processing component.

Congratulations to the following fellows, who were Award Winners at Fellows' Research Day 2011:

  • Kellie Burnside, PhD, for her oral presentation "A Serine/Threonine Kinase and Phosphatase Regulate Hemolysin Expression, Virulence and Antibiotic Resistance in Staphylococcus aureus."
  • Pooja S. Tandon, MD, for her oral presentation "Quantifying the Frequency of Outdoor Play for U.S. Children."
  • Sara Chrisman, MD, for her poster presentation "Risk Factors for Prolonged Concussion in High School Athletes."
  • Xuezhi (Tony) Dai, PhD, for his poster presentation "Developmentally Regulated Expression of MEF2 Proteins Limits the Response to BCR Engagement in Transitional B Cells."
  • Nicholas Madsen, MD, MPH, for his poster presentation "The Pre-participation Physical Evaluation: Are We Living up to Our Standards?"
  • Carter Wray, MD, for his poster presentation "Is Post-resective Intraoperative Electrocorticography Predictive of Seizure Outcomes in Children?"

IV. FACULTY PUBLICATIONS AND PRESENTATIONS

Dr. Thomas Shepard's Catalog of Teratogenic Agents was recently published in its 13th edition by Johns Hopkins Press.

Scott Weissman, MD, is a key lecturer at the Pediatric Antimicrobial Stewardship Conference at Children's Mercy Hospital and Clinics in Kansas City in June. He will be discussing the changing epidemiology of gram negative bacteria.

Drs. Matthew Giefer and Mohamed Oukka: TLR5 Ligand Stimulates Colonic IL-22 Production by LTi-Like Cells in an IL-23R Independent Fashion. Singh A, Giefer MJ, and Oukka M. Gastroenterology. 2011; 140(5): S-496.

Drs. Kihan Kim and Colin Studholme: Fetal hippocampal development: analysis by magnetic resonance imaging volumetry. Jacob FD, Habas PA, Kim K, Corbett-Detig J, Xu D, Studholme C, Glenn OA. Pediatr Res. 2011 May;69(5 Pt 1):425-9.

Drs. Danielle Zerr and Janet Englund: 2009 Pandemic Influenza A (H1N1) Among Health Care Personnel—Duration of Viral Shedding and Implications for Exclusion Recommendations. M Kay, Zerr D, Englund JA, Cadwell BL, Kuypers J, Swenson P, Kwan-Gett TS, Duchin J. Emerg Infect Dis 2011;17: 639-44.

Drs. Kelly Evans, Anne Hing, and Michael Cunningham: Robin sequence: From diagnosis to development of an effective management plan. Evans KN, Sie KC, Hopper RA, Glass RP, Hing AV, Cunningham, ML. Pediatrics May 1 2011; 127, no. 5: 936-948.

Drs. Kristie Bjornson, Chuan Zhou, and William Walker: Relationship of therapy to post-secondary education and employment in young adults with physical disabilities. Bjornson K, Kobayashi A, Zhou C, Walker W. Pediatric Physical Therapy 2011; 23: 179-186.

Drs. Michael Portman, Aaron Olson, and Brian Soriano: Etanercept as adjunctive treatment for acute Kawasaki disease: study design and rationale. Portman MA, Olson A, Soriano B, Dahdah N, Williams R, Kirkpatrick E. Am Heart J. 2011 Mar;161(3):494-9.

Lisa Frenkel, MD:

  1. CD4+ cell count and risk for antiretroviral drug resistance among women using peripartum nevirapine for perinatal HIV prevention. Dorton BJ, Mulindwa J, Li MS, Chintu NT, Chibwesha CJ, Mbewe F, Frenkel LM, Stringer JS, Chi BH. 2011. BJOG 118(4):495-499. PMCID: PMC3076308.
  2. Postpartum viral load rebound in HIV-1-infected women treated with highly active antiretroviral therapy: AIDS Clinical Trials Group Protocol A5150. Sha BE, Tierney C, Cohn SE, Sun X, Coombs RW, Frenkel LM, Kalams SA, Aweeka FT, Bastow B, Bardeguez A, Kmack A, Stek A. 2011. HIV Clin Trials 12(1):9-23.

Drs. Janet Englund and Larry Corey:

  1. Differences in clinical outcomes following influenza A/H1N1 and seasonal influenza among hematopoietic cell transplant recipients. Choi SM, Boudreault A, Xie H, Englund JA, Corey L, Boeckh M. Blood 2011. Mar 3, Epub ahead of print; PMID 21374154.
  2. H275Y mutant pandemic H1N1 2009 virus in immunocompromised patients. Renaud C, Boudreault A, Kuypers J, Lofy K, Corey L, Boeckh M, Englund JA. Emerg Inf Dis 2011; 17:653-60.

Drs. Phoneix Ho and Soheil Meshinchi:

  1. C/EBPα regulated microRNA-34a targets E2F3 during granulopoeisis and acts as tumor suppressor in AML with CEBPA mutations. Pullikan JA, Peramangalam PS, Dengler V, Ho PA, Preudhomme C, Muller-Tidow C, Bohlander SK, Meshinchi S, Tenen DG, Behre G. Blood. 2010;116:5638-5649.
  2. Prevalence and clinical implications of NRAS mutations in childhood AML: a report from the Children's Oncology Group. Berman JN, Gerbing RB, Alonzo TA, Ho PA, Miller K, Hurwitz C, Heerema NA, Hirsch B, Raimondi SC, Lange B, Franklin JL, Gamis A, Meshinchi S.Leukemia. 2011 Mar 1. [Epub ahead of print].

Drs. Phoneix Ho, Jessica Pollard, and Soheil Meshinchi: The WT1 synonymous SNP rs16754 correlates with higher mRNA expression and predicts significantly improved outcome in favorable-risk pediatric AML: a report from the Children's Oncology Group. Ho PA, Kuhn J, Gerbing RB, Pollard JA, Zeng R, Miller KL, Heerema NA, Raimondi SC, Hirsch B, Franklin JL, Lange B, Gamis AS, Alonzo TA, Meshinchi S. J Clin Oncol. 2011;29:704-711.

Drs. Phoenix Ho, Matthew Kutny, and Soheil Meshinchi: Leukemic mutations in the methylation-associated genes DNMT3A and IDH2 are rare events in pediatric AML: a report from the Children's Oncology Group. Ho PA, Kutny MA, Alonzo TA, Gerbing RB, Joaquin J, Raimondi SC, Hirsch BA, Gamis AS, Meshinchi S. Pediatr Blood Cancer. 2011 Apr 18 [Epub ahead of print].

Soheil Meshinchi, MD, PhD: Biology, risk stratification, and therapy of pediatric acute leukemias: an update. Pui CH, Carroll WL, Meshinchi S, Arceci RJ. J Clin Oncol. 2011;29:551-565.

Christian Roth, MD:

  1. Studies of different female rat models of hypothalamic obesity. Elfers C, Ralston M, Roth CL. J Pediatr Endocrinol Metab 2011;24(3-4):131–137.
  2. A novel rodent model that mimics the metabolic sequelae of obese craniopharyngioma patients. Roth CL, Blevins JE, Ralston M, Elfers C, Ogimoto K, Kaiyala KJ, Morton GJ. Pediatr Res. 2011 Mar;69(3):230-6. PubMed PMID: 21372758.
  3. Common variants near MC4R: exploring gender effects in overweight and obese children and adolescents participating in a lifestyle intervention. Vogel CI, Boes T, Reinehr T, Roth CL, Scherag S, Scherag A, Hebebrand J, Hinney A. Obes Facts. 2011;4(1):67-75. Epub 2011 Feb 22. PubMed PMID: 21372613.
  4. Relationship between MTNR1B (melatonin receptor 1B gene) polymorphism rs10830963 and glucose levels in overweight children and adolescents. Reinehr T, Scherag A, Wang HJ, Roth CL, Kleber M, Scherag S, Boes T, Vogel C, Hebebrand J, Hinney A. Pediatr Diabetes. 2011 Mar 3. doi: 10.1111/j.1399-5448.2010.00738.x. [Epub ahead of print] PubMed PMID: 21366812.
  5. Longitudinal association between IGFBP-1 levels and parameters of the metabolic syndrome in obese children before and after weight loss. Reinehr T, Kleber M, Toschke AM, Woelfle J, Roth CL. Int J Pediatr Obes. 2011 Jan 3. [Epub ahead of print] PubMed PMID: 21198359.
  6. Changes in adipose-derived inflammatory cytokines and chemokines after successful lifestyle intervention in obese children. Roth CL, Kratz M, Ralston MM, Reinehr T. Metabolism. 2011 Apr;60(4):445-52. Epub 2010 May 24. PubMed PMID: 20494373.
  7. Appetite-regulating hormone changes in patients with craniopharyngioma. Roth CL, Gebhardt U, Müller HL. Obesity (Silver Spring). 2011 Jan;19(1):36-42. Epub 2010 Apr 8. PubMed PMID: 20379145.

Peter Tarczy-Hornoch, MD, FACMI:

  1. Presented "Amalga in the context of data integration for clinical and translational research" which was broadcasted internationally from Microsoft Research in Redmond WA on January 20th, 2011.
  2. Panel member for "Integrating Genomic and Clinical Data in Electronic Health Records and Biomedical Repositories: Challenges, Solutions and Opportunities" at the AMIA Translational Bioinformatics Summit in San Francisco CA on March 9, 2011
  3. Presented "Connecting Informaton Silos" Informatics Seminar at Vanderbilt in Nashville, TN on March 15, 2011.
  4. Presented "Amalga in the Context of Data Integration for Clinical and Translational Research" at the Biomedical and Health Informatics Research Colloquium on February 1, 2011.
  5. Deriving rules and assertions from pharmacogenomic knowledge resources in support of patient drug response predictions. Overby CL, Devine B, Tarczy-Hornoch P, Kalet I. Intelligent Data Analysis in bioMedicine And Pharmacology (IDAMAP) 2010, November 12, Washington, D.C. IDAMAP 2010 61-66 (2010).
  6. Selected proceedings of the 2010 Summit on Translational Bioinformatics. Mendonca EA, Tarczy-Hornoch P.BMC Bioinformatics. 2010 Oct 28;11 Suppl 9:S1.
  7. Prescriber and staff perceptions of an electronic prescribing system in primary care: A qualitative assessment. Devine EB, Williams EC, Martin DP, Sittig DF, Tarczy-Hornoch P, Payne TH, Sullivan SD. BMC Medical Informatics and Decision Making. 2010 Nov 19;10:72 (2010).
  8. Supporting Retrieval of Diverse Biomedical Data using Evidence-aware Queries. Cadag E, Tarczy-Hornoh P. J Biomed Inform. 2010 Dec;43(6):873-82 (2010).

Please let us know of your latest publications, awards, and honors by emailing Brooke Freed: brooke.freed@seattlechildrens.org