Department Newsletters

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Items to be covered in this edition:

1. Important Dates
2. Welcome to New Faculty
3. Faculty News and Awards
4. Faculty Publications and Presentations

I. IMPORTANT DATES

January 19, 2011: Promotion preparation meeting. 5-6 PM, G1026 at Seattle Children's. The Department of Pediatrics Promotions Committee requires that faculty members who will be considered in the summer/fall of 2011 for promotion to Associate Professor or Professor attend one of these seminars. If you are being considered in 2011 (to be effective July 1, 2012), you, your Division Head and your Division Head’s assistant MUST attend one of these meetings even if you attended one last year (note you do not all need to attend on the same date). For more information or to RSVP your attendance at one of these meetings, contact Diane Wade (dmw@uw.edu or 206.987.1713).

January 27, 2011: CUMG Annual Membership Meeting. 5:30-7:30PM in Sound Café at Seattle Children's. Questions? Contact Ida.Motoshige@seattlechildrens.org

February 9, 2011: SAVE THE DATE for the next Faculty Meeting. More information forthcoming.

February 15, 2011: Promotion preparation meeting. 7:30-8:30 AM, W3747A at Seattle Children's. The Department of Pediatrics Promotions Committee requires that faculty members who will be considered in the summer/fall of 2011 for promotion to Associate Professor or Professor attend one of these seminars. If you are being considered in 2011 (to be effective July 1, 2012), you, your Division Head and your Division Head’s assistant MUST attend one of these meetings even if you attended one last year (note you do not all need to attend on the same date). For more information or to RSVP your attendance at one of these meetings, contact Diane Wade (dmw@uw.edu or 206.987.1713).

April 22, 2011: SAVE THE DATE for Fellows' Research Day. More information and abstract submission information forthcoming.

II. WELCOME TO NEW FACULTY

III. FACULTY NEWS

Benjamin Wilfond, MD, has been elected Vice President/President of the Association of Bioethics Program Directors.

Dr. Wilfond was also awarded $428,000 for a one year project on Research Bioethics Consultation Standardization and Data Sharing from the NCRR through the Institute of Translational Health Sciences. This project will support the work of four national committees, the creation of a web forum, and the development of a software prototype for data-sharing.

Joel Tieder, MD, MPH, has been awarded $1.14 million as site PI in a three year, $9 million PROSPECT grant from AHRQ. The grant will fund an effort to link clinical data (labs and radiology) from the disparate EMRs from 6 pediatric hospitals to a common administrative database (PHIS, run by CHCA) to create PHIS+. The PHIS+ database will be used to answer pediatric comparative effectiveness research questions (several will be conducted under this award) and could also be used for pediatric quality improvement studies that require clinical data.

Drs. Joel Tieder and Tamara Simon have been awarded a grant for 5% salary support from CHCA to serve on the executive council for the Pediatric Research in Inpatient Settings (PRIS) network. PRIS is an independent entity founded through the Society for Hospital Medicine, the American Academy of Pediatrics, and the Academic Pediatric Association. It now has over 200 hospitalists from 80 centers participating in the network, representing centers from the United States and Canada.

Soren Gantt, MD, PhD: Virology Division Innovative Research Pilot Award, $62,000 in direct costs for his project, "Identification of novel drug targets to inhibit human herpes virus replication using the lead compound nelfinavir."

Timothy Cox, PhD received a $195,000 grant funded by the Jorge Posada Foundation entitled "Identifying new genes for craniosynostosis-related midfacial hypoplasia" to investigate the molecular development of midfacial hypoplasia associated with craniosynostosis using mouse models.

IV. FACULTY PUBLICATIONS AND PRESENTATIONS

Jim Stout, MD, MPH, and Charlotte Lewis, MD, MPH: Toothache in US Children. Charlotte Lewis; James Stout. Arch Pediatr Adolesc Med. 2010;164(11):1059-1063

Ben Wilfond, MD and Doug Diekema, MD: Navigating Growth Attenuation in Children with Profound Disabilities: Children’s Interests, Family Decision-Making, and Community Concerns. Benjamin S. Wilfond, Paul Steven Miller, Carolyn Korfiatis, Douglas S. Diekema, Denise M. Dudzinski, Sara Goering, and the Seattle Growth Attenuation and Ethics Working Group. Hastings Center Report 40, no. 6 (2010): 27-40.

Drs. Joseph Flynn and Sandra Watkins: A continuous quality improvement project to decrease hemodialysis catheter infections in pediatric patients: Use of a closed luer-lock access cap. McAfee, N., Seidel, K., Watkins, S., & Flynn, J.T. (2010). Nephrology Nursing Journal, 37(5), 541-545.

William O. Walker, Jr. MD: Discrepancies in Health Care Funding for Individuals with Special Needs. Journal of Pediatric Rehabilitation Medicine 2010; 3: 159-162. Walker WO.

Samuel Zinner, MD: New cases and refinement of the critical region in the 1q41q42 microdeletion syndrome. European Journal of Medical Genetics. Jill A. Rosenfeld, Yves Lacassie, Dima El-Khechen, Luis F. Escobar, James Reggin, Carolyn Heuer, Emily Chen, Lauren S. Jenkins, A. Thomas Collins, Samuel Zinner, Melanie Babcock, Bernice Morrow, Roger A. Schultz, Beth Torchia, Blake C. Ballif, Karen D. Tsuchiya and Lisa G. Shaffer.

Cora Collette Breuner, MD, MPH: Complementary, Holistic, and Integrative Medicine: Eating Disorders. Pediatrics in Review. 2010;31:e75-e82. doi:10.1542/pir.31-10-e75

Ken Feldman, MD: Neck and spinal cord injuries in child abuse. For: Child Abuse and Neglect: Diagnosis, Treatment and Evidence. Boos S and Feldman K. Jenny C, ed. Elsevier, Saunders. St. Louis, Mo 2010:392-401.

Bonnie Ramsey, MD: Effect of VX-770 in persons with cystic fibrosis and the G551D-CFTR mutation. N Engl J Med 2010 Nov 18; 363:1991. Accurso FJ et al.

Daniella Luquetti, MD, PhD: Birth defects quality reporting by the Brazilian Birth Certificate: comparative study in 2004 and 2007. Cad Saude Publica. 26(9): 1756-65, 2010. Luquetti DV, Koifman RJ.

Anne Hing, MD: FOXE1 association with both isolated cleft lip with or without cleft palate, and isolated cleft palate. Hum Mol Genet 2009; 18(24):4879-4896. Moreno LM, Mansilla MA, Bullard SA, Cooper ME, Busch TD, Machida J, Johnson MK, Brauer D, Krahn K, Daack-Hirsch S, L'heureux J, Valencia-Ramirez C, Rivera D, López AM, Moreno MA, Hing AV, Lammer EJ, Jones M, Christensen K, Lie RT, Jugessur A, Wilcox AJ, Chines P, Pugh E, Doheny K, Arcos-Burgos M, Marazita ML, Murray JC, Lidral AC.

Carrie Heike, MD, MS: 3D digital stereophotogrammetry: a practical guide to facial image acquisition. Head Face Med. 2010 Jul 28;6:18. Heike CL, Upson K, Stuhaug E, Weinberg SM.

Carrie Heike, MD, MS, and Jackie Starr, PhD: Increased risk of orofacial clefts associated with maternal obesity: case-control study and Monte Carlo-based bias analysis. Paediatr Perinat Epidemiol. 2010 Sep;24(5):502-12. Stott-Miller M, Heike CL, Kratz M, Starr JR.

Carrie Heike, MD, MS, Jackie Starr, PhD, and Michael Cunningham, MD, PhD: Three-dimensional head shape quantification for infants with and without deformational plagiocephaly. Cleft Palate Craniofac J. 2010 Jul;47(4):368-77. Atmosukarto I, Shapiro LG, Starr JR, Heike CL, Collett B, Cunningham ML, Speltz ML.

Jackie Starr, PhD: Mothers' and Fathers' Reports of Stress in Families of Infants with and without Single-Suture Craniosynostosis. Cleft Palate Craniofac J. 2010 Aug 19. [Epub ahead of print] Rosenberg J, Kapp-Simon K, Starr J, Cradock M, Speltz M.

Jackie Starr, PhD, and Michael Cunningham, MD, PhD:

1. Nasopharyngeal airway for management of airway obstruction in infants with micrognathia. Cleft Palate Craniofac J 2010; August 17 [Epub ahead of print]. Parhizkar N, Saltzman B, Grote K, Starr JR, Cunningham ML, Perkins J, Sie K.
2. Pediatric sleep apnea and craniofacial anomalies: a population-based case-control study. Laryngoscope 2010; Sep 7 [Epub ahead of print]. Lam DJ, Jensen CC, Mueller BA, Starr JR, Cunningham ML, Weaver EM.

Michael Cunningham, MD, PhD:

1. Disease Risk of Missense Mutations using Structural Inference from Predicted Function. Curr Protein Pept Sci. 2010 Nov 4. [Epub ahead of print] Horst JA, Wang K, Horst OV, Cunningham ML, Samudrala R.
2. Little evidence of association between severity of trigonocephaly and cognitive development in infants with single-suture metopic synostosis. Neurosurgery 2010;67(2):408-415; discussion 415-416. Starr JR, Lin HJ, Ruiz-Correa S, Cunningham ML, Ellenbogen RG, Collett BR, Kapp-Simon KA, Speltz ML.

Timothy Cox, PhD:

1. Purifying natively folded proteins from inclusion bodies with sarkosyl, Triton X-100 and CHAPS. BioTechniques. 48:61-64. Tao, H., Liu, W., Simmons, B.N., Harris, H.K., Cox, T.C., & Massiah, M.A. (2010)
2. Maternal ethanol consumption alters the epigenotype and the phenotype of offspring in a mouse model. PLoS Genetics 6(1) doi:10.1371/journal.pgen.1000811. Kaminen-Ahola, N., Ahola, A., Maga, M., Mallitt, K-A., Fahey, P., Cox, T.C., Whitelaw, E., & Chong, S. (2010)
3. Cyclin-dependent Kinase-like 5 (CDKL5) mutation screening in Rett Syndrome and related disorders. Twin Research and Human Genetics 13(2):168-178. White, R., Ho, G., Schmidt, S., Scheffer, I.E., Fischer, A., Yendle, S.C., Bienvenu, T., Nectoux, J., Ellaway, C.J., Darmanian, A., Tong, X.Z., Cloosterman, D., Bennetts, B., Kalra, V., Fullston, T., Gecz, J., Cox, T.C., & Christodoulou, J. (2010)
4. Vascular remodeling of the vitelline artery initiates extra-vascular emergence of hematopoietic clusters. Blood 116(18):3435-3444. Zovein, A.C., Turlo, K.A., Ponec, R.W., Lynch, M.R., Chen, K.C., Hofmann, J.J., Cox, T.C., Gasson, J.C., & Iruela-Arispe, M.L. (2010)
5. Published Abstract: The anatomy of the posterior urethra by optical projection tomography. Society for Pediatric Pathology Spring Meeting. Washington, DC. Mar 2010. [Modern Pathol 23: 323 (2010)] Siebert, J.R., Cox, T.C. & Glass, I.A.

Rachel Katzenellenbogen, MD:

1. NFX1 plays a role in human papillomavirus type 16 E6 activation of NFkappaB activity. Xu M, Katzenellenbogen RA, Grandori C, Galloway DA. J Virol. 2010 Nov;84(21):11461-9.
2. Cytoplasmic poly(A) binding proteins regulate telomerase activity and cell growth in human papillomavirus 16 E6 expressing keratinocytes. Katzenellenbogen RA, Vliet-Gregg P, Xu M, Galloway DA. J Virol. 2010 Oct 13. [Epub ahead of print] PMID: 20943973

Janet Englund, MD:

1. Viral Respiratory Infections in Hospitalized and Community Control Children in Alaska. J Med Virol 2010; 82:1282-90. Singleton RJ, Bulkow LR, Miernyk K, DeByle C, Pruitt L, Boyd-Hummel K, Bruden D, Englund JA, Anderson L, Lucher L, Holman RC, Hennessy TW.
2. Development of a symptom score to identify children with a documented viral upper respiratory tract infection. Ped Res 2010; 68:252-7. Taylor JA, Weber WJ, Martin ET, McCarty RL, Englund JA.
3. Epidemiology of Viral Respiratory Tract Infections in a Prospective Cohort of Infants and Toddlers Attending Daycare. J Clin Vir 2010; 49: 16-20. Fairchok MP, Martin ET, Chambers S, Kuypers J, Behrens M, Braun LE, Englund JA.
4. Outpatient viral upper respiratory tract infections in children with malaria symptoms in western Kenya. Am J Trop Med, 2010; 83:1010-3. Waitumbi J, Kuypers J, Anyona SB, Koros JN, Polhemus ME, Gerlach J, Steele M, Englund JA, Neuzil KM, Domingo GJ.

Please let us know of your latest publications, awards, and honors by emailing Brooke Freed: brooke.freed@seattlechildrens.org