Department Newsletters

Department of Pediatrics Newsletter
October 15, 2010

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Items to be covered in this edition:

  1. Important Dates
  2. Welcome to New Faculty
  3. Leadership Change in Bone Marrow Transplantation
  4. Faculty News and Awards
  5. Faculty Publications and Presentations

I. IMPORTANT DATES

October 19: Meeting of Professors and Associate Professors to discuss non-mandatory promotions. 8:00-9:00 AM, W3747A with videoconferencing to Pearl Jam. Contact Diane Wade (dmw@uw.edu or 206-987-1713) with questions.

October 21: The annual Work Life Balance Symposium and Lana Staheli Endowed Lecture will take place on Thursday, October 21 and will feature Dr. Perri Klass who will give grand rounds and the Keynote Lecture for the symposium. The theme of the symposium will be, “Pursue your passion: Creating a balance and satisfying life.” Contact: Kathie.Kohorn@seattlechildrens.org

October 22: The Division of Medical Genetics presents the 2nd Annual Arno and Gretel Motulsky Lecture featuring D. Holmes Morton, MD, Co-Founder & Clinic Director, The Clinic for Special Children. “Caring for the Patient” in the Time of Genomics Small Science in a Rural Clinic.3:30PM at UW Health Sciences Building T-733. Reception immediately following at South Campus Center Room 316. RSVP: medgen@uw.edu

October 25: Department of Pediatrics Fall Faculty meeting. Wright Auditorium from 5:15-7:30 PM (5:15-5:45 PM social gathering with buffet service of assorted hors' d'oeuvres and appetizers; 6:15-7:30 PM meeting). The focus will be on Patient Safety. Contact Diane Wade (dmw@uw.edu or 206-987-1713) with questions.

October 27: Promotion Criteria meeting. 5-6:30pm G-1026, Seattle Children’s Hospital. Acting Instructors, Acting Assistant Professors, Assistant Professors, Research Assistant Professors, New Faculty and Interested Faculty: Chris Gleason and Fred Rivara give a talk annually for faculty on promotion criteria for different faculty tracks and the promotion process. The goal is to take some of the mystery out of the process, help you think ahead to what are the components of the promotion packet that need to be assembled, and to prepare now to make this process less stressful. This is intended for junior faculty as well as all new faculty so that all can understand the criteria and process. Please RSVP to Diane Wade (dmw@uw.edu) if you would like to attend.

November 1: UW Child Health Research Center application deadline. The UW Child Health Research Center is a K12 (career development) grant and is meant for faculty on the clinician-scientist track who have an interest in basic science research. It provides support during the transition from trainee to junior faculty status. This opportunity is open to all Board-certified pediatricians who have completed a subspecialty fellowship. Applications are available from the Program Director’s office. To obtain an application, please email Mackenzie.Orgill@seattlechildrens.org before Friday, October 22, 2010. Completed applications are due in the Program Director’s office by Monday, November 1, 2010.

II. WELCOME TO NEW FACULTY

Name

Rank

Division

New Appointments

Steven Bachta, MD

FTCF-Clinical Instructor

Hospital Medicine

Susan Halbach, MD

Acting Assistant Professor

Nephrology

Sarah Hilgenberg, MD

FTCF-Clinical Instructor

Hospital Medicine

Beth Ogata, MS, RD

Teaching Associate

Genetics

Aarati Rao, MD

FTCF-Clinical Assistant Professor

Hospital Medicine

Johannes Von Alvensleben, MD

FTCF-Clinical Instructor

Hospital Medicine

III. LEADERSHIP CHANGE IN BONE MARROW TRANSPLANTATION

We want to make you aware of the following transition in leadership in the Division of Pediatric Hematology-Oncology and also to acknowledge the lifetime contributions of Jean Sanders, MD, who will be transitioning as medical director of our pediatric bone marrow transplant service. Jean has made a unique and permanent influence on the lives of children with cancer and other marrow disorders. The development of pediatric marrow transplantation is synonymous with her career. We thank and congratulate her on her many achievements and also express our gratitude for her remaining with our Division and Department following the transition.

We are also pleased to announce that Scott Baker, MD, will become the medical director of the pediatric bone marrow transplant service effective January 1, 2011. He and Jean will be working together in the next two and a half months. Please congratulate Scott on this appointment. We know that he will provide outstanding leadership to continue Jean’s standard of excellence.

IV. FACULTY NEWS & AWARDS

The American Academy for Cerebral Palsy and Developmental Medicine (AACPDM) recognized Dr. Jeff McLaughlin, Professor Emeritus, Department of Pediatrics, Division of Developmental Medicine, at their 64th Annual Meeting with the 2010 Mentorship Award. This award recognizes an individual who has demonstrated outstanding leadership for trainees and colleagues in the field of cerebral palsy and other developmental disabilities. In honoring Dr. McLaughlin, the academy noted the depth and breadth of his contributions and impact on improving services and care, promoting professional education and research for individuals with disabilities and his lifetime commitment to mentorship. Dr. McLaughlin served as President of AACPDM in 1992.

Ben Wilfond, MD, was elected as a Fellow of The Hastings Center. The Hastings Center is an independent, nonpartisan, and nonprofit bioethics research institute founded in 1969. The Center's mission is to address fundamental ethical issues in the areas of health, medicine, and the environment as they affect individuals, communities, and societies. Hastings Center Fellows are an elected association of leading researchers influential in the fields in which the Center is engaged.

Mark Del Beccaro, MD has been elected Chair of the AAP Council on Clinical Information Technology (July 2010).

Florence Wu, MD, Pediatric Resident, was selected to serve on the UW Graduate Medical Education Committee for the 2010-2011 term.

Jon R. Almquist, MD, Clinical Professor Emeritus, was awarded with the Clifford G. Grulee Award by the AAP which recognizes outstanding service to the Academy beyond that required of the elected leadership. Dr. Almquist has served as president of the Washington Chapter of the AAP and was chair of AAP District VIII. He has also served as the chair of the AAP Task Force on Immunization and on the National Vaccine Advisory Committee.

Leslie R. Walker, MD, Chief, Division of Adolescent Medicine received notice that the Drug Free Communities community coalition substance abuse prevention grant was awarded to Seattle Children’s Hospital: Prevention Works in Seattle. It is for $125,000 for 5 years. Information about the DFC program and Drug Free Communities grantees can be accessed at the DFC website: http://www.ondcp.gov/dfc/

Catherine Pihoker, MD and the Division of Endocrinology received a grant award from the CDC for projects SEARCH for Diabetes in Youth 3, components A and B. These two projects will study trends in incidence of pediatric diabetes including trends in incidence of diabetes by diabetes type and clinical characteristics, development of a public health surveillance system for diabetes, risk factors for acute and chronic complications, and factors affecting quality of care. This is an extension of work in SEARCH1 and 2 that the division has been a part of for the past 10 years. Four other sites are participating (Cincinnati Children’s, University of Colorado, University of North Carolina, and Kaiser Permanente Southern California). Dr. Pihoker is the PI for this site, and co-investigators are Lenna Liu, MD, MPH, Angela Badaru, MB, John Neff, MD, Joyce Yi-Frazier, PhD, andLisa Gilliam MD, PhD. This is a 5 year award for both components, together totaling $3.2 million over the funding period.

The Division of Hematology-Oncology has launched a new website which can be found at: http://pedsfellowship.fhcrc.org/

Drs. Mary King and Jerry Zimmerman were awarded an AAP Conference Critical Care Section 2010 best abstract for their project: How a Little Sedation Protocol Can Have a Big Impact On a Pediatric Intensive Care Unit. AAP Conference, Critical Care Section, San Francisco 2010. Deeter K, King MA, Zimmerman JZ.

Luke Hoffman, MD, PhD: Center for Clinical and Translational Research Pediatric Pilot Funds, Title: Community-level physiologic profiling: A novel method for studying chronic, polymicrobial infections. October, 2010-September, 2011. Annual Direct Cost: $20,000

Dr. Lisa Frenkel received the following grant awards:

  1. “HIV-1 evolution in the female genital tract and trafficking in the blood”. Dr. Frenkel will determine if monotypic (identical) HIV env sequences in the uterine cervix result from proliferation of infected cells or from bursts of viral replication. She will also determine if whole monotypic HIV genomes include replication competent viruses. NIH / NIAID. $606,075. 09/15/10-08/31/11
  2. International Maternal Pediatric Adolescent AIDS Clinical Trials Group ("IMPAACT").Anti-HIV medicines are given to pregnant women to prevent passing the virus to their babies. Learning how to give these medicines without causing the virus to become resistant to these medicines, and developing inexpensive technology to assess HIV drug-resistance is important for the health of HIV-infected women, as resistant viruses make it more difficult or more costly to effectively treat HIV infection. ARRA sub contract with Social Scientific Systems. $426,609. 09/13/10 – 09/12/11

V. FACULTY PUBLICATIONS AND PRESENTATIONS

Lincoln Smith, MD will be presenting an abstract at the Salk/Nature/Fondation IPSEN 5th annual Symposium on Biological Complexity: Emerging Concepts and Trends. L.S. Smith, S.A. Gharib, and T.R. Martin. Lung Development Modifies the Innate Immune Responses to Inhaled Lipopolysaccharide.

Drs. Maya Hughes (resident), Matthew Kutny (fellow), Jessica Pollard, and Phoenix Ho will be presenting abstracts at the 52nd Annual Meeting of the American Society of Hematology (ASH) December 4-December 7, 2010, in Orlando, Florida.

Drs. Emily Hartford and Charlene Wong (pediatric residents) presented abstracts at the 2010 AAP meeting in San Francisco on October 2nd.

Tyler Burpee, MD: Intestinal ferroportin expression in pediatric Crohn's disease. Burpee T, Mitchell P, Fishman D, Islam S, Nemeth E, Westerman M, Wessling-Resnick M, Grand RJ. Inflamm Bowel Dis. 2010 Jun 17.

Brian D. Soriano, MD: Validation of 3-Dimensional Echocardiographic Assessment of Left Ventricular Volumes, Mass, and Ejection Fraction in Neonates and Infants with Congenital Heart Disease: A Comparison Study with Cardiac Magnetic Resonance Imaging. Friedberg MK, Su X, Tworetzky W, Soriano BD, Powell AJ, Marx GR. Circ Cardiovasc Imaging. 2010 Sep 20. [Epub ahead of print] PMID: 20855861

Luke Hoffman, MD, PhD: Revealing the dynamics of polymicrobial infections: implications for antibiotic therapy. Rogers GB, Hoffman LR, Whitely M, Daniels TVW, Carroll MP,and Bruce KD. Trends in Microbiology, 2010;18(8):357-64.

Drs. Ryan McAdams, Christine Gleason, and Sandra Juul: Left ventricular hypertrophy is prevalent in Sprague-Dawley rats. Comparative Medicine 60: 1-7, 2010. McAdams RM, McPherson RJ, Dabestani NM, Gleason CA, Juul SE.

Maureen Kelley, PhD: Should International Adoption be Part of Humanitarian Aid Efforts? Lessons from Haiti. Bioethics. Volume 24 Number 7 2010 pp 373–380.

Isabella Knox, MD: Tongue tie and frenotomy in the breastfeeding newborn. Knox I. NeoReviews 2010; 11: 513-519.

Mark Del Beccaro, MD: Decision Support Alerts for Medication Ordering in a Computerized Provider Order Entry (CPOE) System: A systematic approach to decrease alerts. Del Beccaro MA, Villanueva R, Knudson KM, Harvey EM, Langle JM, Paul W. Appl Clin Inf 2010; 1 3: 346-362.

Dimitri Christakis, MD, MPH: Making Research Matter: Promoting Dissemination and Sustainability. Academic Pediatrics, Vol 10, No 5, Sept-Oct 2010.

Daniel G. Miller, MD, PhD: A Unifying Genetic Model for Facioscapulohumeral Muscular Dystrophy. Richard J. L. F. Lemmers, Patrick J. van der Vliet, Rinse Klooster, Sabrina Sacconi, Pilar Camaño, Johannes G. Dauwerse, Lauren Snider, Kirsten R. Straasheijm, Gert Jan van Ommen, George W. Padberg, Daniel G. Miller, Stephen J. Tapscott, Rabi Tawil, Rune R. Frants, Silvère M. van der Maarel. Originally published in Science Express on 19 August 2010, Science 24 September 2010: Vol. 329. no. 5999, pp. 1650 – 1653. DOI: 10.1126/science.1189044

Lincoln Smith, MD: Activation of Fas receptor impairs alveolar epithelial function in mouse lungs. Poster Presentation at the European Respiratory Society, 2010 Annual Congress, Barcelona, Spain. Herrero R, Smith L, Kajikawa O, Wong VA, Mongovin S, Matute-Bello G, Martin TR.

Drs. Gwen Glew and William O. Walker, Jr: “Bullying Update: Are We Making Any Progress?” Pediatrics in Review 2010; 31: e68-74. Glew GM, Frey KS, Walker WO.

Ofer Yanay, MD: Prolonged survival and improved glycemia in BB diabetic rats after early sustained exposure to GLP-1. Yanay O, Moralejo D, Kernan, K, Brzezinski M, Fuller J, Barton R, Lernmark A, Osborne W. J gene med. 2010 June 12(6)538-544.

Mary King, MD: King MA, Koelemay K, Zimmerman J, Rubinson. Geographical maldistribution of pediatric medical resources in Seattle-King County. Prehosp Disaster Med. 2010 Jul-Aug;25(4):326-32.

Ken Schenkman, MD: Simultaneous Optical Spectroscopic Measurement of Hemoglobin and Myoglobin Saturations and Cytochrome aa3 Oxidation In Vivo. Arakaki, L.S.L., Ciesielski, W.A., Thackray, B.D., Feigl, E.O., and Schenkman, K.A. Applied Spectroscopy, 64(9) 973-979, 2010.

Drs. Thomas N. Hansen, Skip Smith, and Peter Richardson: Noninvasive respiratory support of juvenile rabbits by high-amplitude bubble continuous positive airway pressure. DiBlasi RM, Zignego JC, Tang DM, Hildebrandt J, Smith CV, Hansen TN, Richardson CP. Pediatr Res. 2010 Jun;67(6):624-9.

Drs. Maneesh Batra, Thomas N. Hansen, and Craig Rubens: Global report on preterm birth and stillbirth (3 of 7): evidence for effectiveness of interventions. Barros FC, Bhutta ZA, Batra M, Hansen TN, Victora CG, Rubens CE; GAPPS Review Group. BMC Pregnancy Childbirth. 2010 Feb 23;10 Suppl 1:S3. Review.PMID: 20233384

Drs. Joseph Flynn and Jane Rees: Isradipine for Treatment of Acute Hypertension in Hospitalized Children and Adolescents. Yosuke Miyashita, MD, MPH; Do Peterson, MS; Jane M. Rees, PhD, MS, RD; Joseph T. Flynn, MD, MS. J Clin Hypertens

Joseph T. Flynn MD, MS:

  1. Hypertension in neonates. Flynn JT. Lebanese Medical Journal, 58:149-155, 2010.
  2. A Continuous Quality Improvement Project to Decrease Hemodialysis Catheter Infections in Pediatric Patients: Use of a Closed Luer-Lock Access Cap. N McAfee, K Seidel, S Watkins, JT Flynn. Nephrology Nursing Journal September-October 2010 Vol. 37, No. 5
  3. Dyslipidemia in children with chronic kidney disease. Jeffrey M. Saland, Christopher B. Pierce, Mark M. Mitsnefes, Joseph T. Flynn, Jens Goebel, Juan C. Kupferman, Bradley A. Warady and Susan L. Furth, on behalf of the CKiD Investigators. Kidney International advance online publication, 25 August 2010; doi:10.1038/ki.2010.311

Tamara Simon, MD, MSPH:

  1. Reinfection following initial cerebrospinal fluid shunt infection Clinical Article 277. Journal of Neurosurgery: Pediatrics. Volume 6, Number 3, September 2010, pp. 277-285. Tamara D. Simon, Matthew Hall, J. Michael Dean, John R.W. Kestle, and Jay Riva-Cambrin
  2. Children with Complex Chronic Conditions in Inpatient Hospital Settings in the U.S. Pediatrics. Volume 126, Number 4. October 2010. Tamara D. Simon, Jay Berry, Chris Feudtner, Bryan L. Stone, Xiaoming Sheng, Susan L. Bratton, J. Michael Dean, Rajendu Srivastava.

Please let us know of your latest publications, awards, and honors by emailing Brooke Freed: brooke.freed@seattlechildrens.org