Blast Waves and Brain Damage

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Recently, doctors have debated the cause of neurological problems affecting many soldiers returning from Iraq and Afghanistan. Some say symptoms such as memory loss, mood swings and insomnia are due to psychological conditions like depression or post-traumatic stress disorder. But now, a team of UW and Veterans Affairs researchers has gathered the first direct evidence that blast waves from roadside bombs can cause long-term changes in soldiers’ brains.

The team conducted positron emission tomography (PET) scans in 12 Iraq veterans who had been exposed to an average of 14 roadside bomb blasts. Compared with a group of 12 volunteers who had never served in the military, the soldiers showed reduced activity in four areas of the brain linked to emotion, language, mental focus and sleep.

“We’re the first people to establish that there are objectively observable brain changes in veterans who have had these multiple blast concussions,” says Elaine Peskind, professor of psychiatry and behavioral sciences, who led the research team.

Since those results were published online in the journal NeuroImage in April, the researchers have performed PET scans in nine more blast-exposed veterans.

“The findings have gotten stronger,” Peskind says. “The differences between the two groups become more pronounced as we add more subjects.” They’ve also begun doing scans using a specialized form of magnetic resonance imaging (MRI), which are revealing structural changes in the soldiers’ brains.

They’re also taking samples of the soldiers’ spinal fluid to look for molecules that could indicate an increased risk of developing dementia in the future. “This is a really new phenomenon,” says Peskind. It’s not clear what these brain changes mean for the veterans and active-duty soldiers over the long term, but Peskind and her team plan to continue piecing the puzzle together.
Sarah DeWeerdt

3 Responses to Blast Waves and Brain Damage

  1. Nancy Berkowitz says:

    With increasing evidence that our brains can continue to grow and develop throughout our lifespan, my hope is that those who have experienced blast waves from roadside bombs have available to them therapies facilitating this growth – such as Internal Family Systems or mindfullness-based psychotherapy.

  2. Debbie Greene says:

    Found your article “Brain Waves and Brain Damage” very interesting. I would like to read more about the research and findings on this subject. Could you direct me to some websites that would have that information. I couldn’t find the article in Neurolmage. I have a nephew in the Marines who just returned from a tour in Afghanistan (also has done a tour in Iraq)so I’m concerned and would like to know more about symptoms and treatment. Thank you if you have any information you can share with me.

  3. Sarah DeWeerdt says:

    Hi Debbie, thanks for your interest in my Columns article. The full text of the Neuroimage article isn’t freely available online, but you can read an abstract here:
    http://www.ncbi.nlm.nih.gov/pubmed/20385245
    At that link, you will see a lot of “related articles” to the right of the abstract: this is an extremely active area of research right now. I don’t think we have any definitive answers yet about treatment, but Dr. Peskind and others are continuing to do research in this area.
    Many thanks to your nephew for his service.

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